Article (Scientific journals)
Outcomes of Advanced Hodgkin Lymphoma after Umbilical Cord Blood Transplantation: A Eurocord and EBMT Lymphoma and Cellular Therapy & Immunobiology Working Party Study
Paviglianiti, A.; Tozatto Maio, K.; Rocha, V. et al.
2018In Biology of Blood and Marrow Transplantation, 24, p. 2265-2270
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Keywords :
Adult patients; Hodgkin lymphoma; Umbilical cord blood transplantation
Abstract :
[en] Allogeneic stem cell transplantation is an alternative for patients with relapsed or refractory Hodgkin lymphoma (HL), but only limited data on unrelated umbilical cord blood transplantation (UCBT) are available. We analyzed 131 adults with HL who underwent UCBT in European Society for Blood and Marrow Transplantation centers from 2003 to 2015. Disease status at UCBT was complete remission (CR) in 59 patients (47%), and almost all patients had received a previous autologous stem cell transplantation. The 4-year progression-free survival (PFS) and overall survival (OS) were 26% (95% confidence interval [CI], 19% to 34%) and 46% (95% CI, 37% to 55%), respectively. Relapse incidence was 44% (95% CI, 36% to 54%), and nonrelapse mortality (NRM) was 31% (95% CI, 23% to 40%) at 4 years. In multivariate analysis refractory/relapsed disease status at UCBT was associated with increased relapse incidence (hazard ratio [HR], 3.14 [95% CI, 1.41 to 7.00], P =.005) and NRM (HR, 3.61 [95% CI, 1.58 to 8.27], P =.002) and lower PFS (HR, 3.45 [95% CI, 1.95 to 6.10], P <.001) and OS (HR, 3.10 [95% CI, 1.60 to 5.99], P =.001). Conditioning regimen with cyclophosphamide + fludarabine + 2 Gy total body irradiation (Cy+Flu+2GyTBI) was associated with decreased risk of NRM (HR,.26 [95% CI,.10 to.64], P =.004). Moreover, Cy+Flu+2GyTBI conditioning regimen was associated with a better OS (HR,.25 [95% CI,.12 to.50], P <.001) and PFS (HR,.51 [95% CI,.27 to.96], P =.04). UCBT is feasible in heavily pretreated patients with HL. The reduced-intensity conditioning regimen with Cy+Flu+2GyTBI is associated with a better OS and NRM. However, outcomes are poor in patients not in CR at UCBT. © 2018
Disciplines :
Hematology
Author, co-author :
Paviglianiti, A.;  Eurocord, Hôpital Saint Louis, Paris, France, Monacord, Centre Scientifique de Monaco, Monaco
Tozatto Maio, K.;  Eurocord, Hôpital Saint Louis, Paris, France, Monacord, Centre Scientifique de Monaco, Monaco
Rocha, V.;  Eurocord, Hôpital Saint Louis, Paris, France, Monacord, Centre Scientifique de Monaco, Monaco, Department of Haematology, Hospital Sao Paulo, San Paulo, Brazil
Gehlkopf, E.;  Service d'Hématologie, CHU Lapeyronie, Montpellier, France
Milpied, N.;  Service d'Hématologie et Thérapie Cellulaire, Hôpital Haut-leveque, CHU Bordeaux, Pessac, France
Esquirol, A.;  Clinical Hematology Service, Hospital de la Santa Creu i Sant Pau, Jose Carreras Leukaemia Research Institute, Barcelona, Spain
Chevallier, P.;  Service d'hématologie, Hotel Dieu, Nantes, France
Blaise, D.;  Service d'Hématologie et thérapie cellulaire, Institute Paoli Calmettes, Marseille, France
Gac, A.-C.;  Institut d'Hématologie de Basse-Normandie, Caen, France
Leblond, V.;  Hematologie Clinique, Hopital la Pitié-Salpêtrière, Paris, France
Cahn, J. Y.;  Hématologie Clinique, CHU Grenoble Alpes, Grenoble, France
Abecasis, M.;  BMT Unit, Institute Portugues Oncologia, Lisbon, Portugal
Zuckerman, T.;  Department of Hematology and BMT, Rambam Medical Center, Haifa, Israel
Schouten, H.;  Department of Internal Medicine, Hematology and Oncology, University Hospital Maastricht, Maastricht, Netherlands
Gurman, G.;  Department of Hematology Adult Stem Cell Transplantation Unit, Ankara University, Ankara, Turkey
Rubio, M. T.;  Service d'Hematologie et Therapie Cellulaire, Hôpitaux des Brabois, Nancy, France
Beguin, Yves  ;  Université de Liège - ULiège > GIGA-R : Hématologie
Corral, L. L.;  Hematology Department, Complejo Asistencial Universitario de Salamanca-IBSAL, Centro de Investigacion del Cancer-IBMCC, Salamanca, Spain
Nagler, A.;  Department of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel
Snowden, J. A.;  Department of Haematology, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom
Koc, Y.;  Stem Cell Transplant Unit Medical Park Hospitals, Antalya, Turkey
Mordini, N.;  Division of Hematology, Az. Ospedaliera S. Croce e Carle, Cuneo, Italy
Bonifazi, F.;  Institute of Hematology, “Seragnoli” University Hospital S. Orsola-Malpighi, Bologna, Italy
Volt, F.;  Eurocord, Hôpital Saint Louis, Paris, France, Monacord, Centre Scientifique de Monaco, Monaco
Kenzey, C.;  Eurocord, Hôpital Saint Louis, Paris, France, Monacord, Centre Scientifique de Monaco, Monaco
Robinson, S. P.;  Bristol Oncology Centre, EBMT Lymphoma Working Party, Bristol, United Kingdom
Montoto, S.;  Department of Haemato-Oncology, St. Bartholomew's Hospital, Barts Health NHS Trust, EBMT Lymphoma Working Party, London, United Kingdom
Gluckman, E.;  Eurocord, Hôpital Saint Louis, Paris, France, Monacord, Centre Scientifique de Monaco, Monaco
Ruggeri, A.;  Eurocord, Hôpital Saint Louis, Paris, France, Monacord, Centre Scientifique de Monaco, Monaco, Hematology Department, Ospedale Pediatrico Bambin Gesù, Dipartimento di Oncoematologia e Terapia Cellulare e Genica, Rome, Italy
More authors (19 more) Less
Language :
English
Title :
Outcomes of Advanced Hodgkin Lymphoma after Umbilical Cord Blood Transplantation: A Eurocord and EBMT Lymphoma and Cellular Therapy & Immunobiology Working Party Study
Publication date :
2018
Journal title :
Biology of Blood and Marrow Transplantation
ISSN :
1083-8791
eISSN :
1523-6536
Publisher :
Elsevier Inc.
Volume :
24
Pages :
2265-2270
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 January 2019

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