Reference : Interest of cylodextrins in spray-dried microparticles formulation for sustained pulm...
Scientific congresses and symposiums : Poster
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/231941
Interest of cylodextrins in spray-dried microparticles formulation for sustained pulmonary delivery of budesonide
English
Bigazzi, William mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Dufour, Gilles []
De Tullio, Pascal mailto [Université de Liège - ULiège > Département de pharmacie > Chimie pharmaceutique >]
Piel, Géraldine mailto [Université de Liège - ULiège > Département de pharmacie > Développement de nanomédicaments >]
Cataldo, Didier mailto [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Evrard, Brigitte mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Jun-2017
No
International
EuroDrying’2017 – 6th European Drying Conference
du 19 juin 2017 au 21 juin 2017
Liège
Belgique
[en] cyclodextrins ; budesonide ; spray-drying
[en] The present study aim at developing cyclodextrin-based spray-dried microparticles containing a corticosteroid (budesonide) with an efficient lung delivery and efficacy. Complexation between budesonide and hydroxypropyl-beta-cyclodextrin (HPBCD) has been investigated and production of spray-dried powder was optimized based on a design of experiments. Wrinkled particles associated with a low bulk density and improved respirable fraction in comparison to a marketed product were obtained. An in vitro test showed that HPBCD is able to decrease the permeability of budesonide across the bronchial epithelium by a sustained release effect. In conclusion, this work reports that the use of cyclodextrin in the formulation of dry powder for inhalation is of a double interest as it both improves respirable fraction and lung residence time of budesonide.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
Walloon region
AEROGAL project
Researchers ; Professionals
http://hdl.handle.net/2268/231941

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Open access
Poster Eurodrying 2017.pptxPublisher postprint1.74 MBView/Open

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.