No full text
Unpublished conference/Abstract (Scientific congresses and symposiums)
Tumor microenvironment affects the composition of endothelial-derived exosomes: impact in tumor progression
Njock, Makon-Sébastien; O'Grady, Tina; Nivelles, Olivier et al.
2018GIGA-CANCER DAY
 

Files


Full Text
No document available.

Send to



Details



Abstract :
[en] The tumor microenvironment plays a crucial role in the progression of tumor growth and metastasis by deregulating various physiological processes including angiogenesis and inflammation. Several studies have previously demonstrated that tumor-derived exosomes are actively involved in the mediation of tumorigenesis by “reprogramming” target cells (e.g. endothelial cells (ECs)) through transfer of pro-angiogenic microRNAs. But the function of exosomes released by target cells is poorly studied. Consequently, we sought to determine the composition of exosomes released by ECs under tumor microenvironment, and to assess whether these vesicles present different functional properties. Using RNA-seq approaches, we demonstrated that exosomes released by ECs in tumor microenvironment context present a specific repertory of microRNAs associated to tumor angiogenesis and inflammatory pathways. Furthermore, we showed that these vesicles were able to optimize inflammatory response of immune cells by transferring several dysregulated microRNAs. Currently, we are identifying the molecular pathways modulated by endothelial-derived exosomes in tumor microenvironment.
Research center :
GIGA‐R - Giga‐Research - ULiège
Disciplines :
Oncology
Author, co-author :
Njock, Makon-Sébastien  ;  Université de Liège - ULiège > Cancer-Molecular Angiogenesis Laboratory
O'Grady, Tina ;  Université de Liège - ULiège > Département des sciences de la vie > Génétique et biologie moléculaires animales
Nivelles, Olivier ;  Université de Liège - ULiège > Cancer-Molecular Angiogenesis Laboratory
Dequiedt, Franck  ;  Université de Liège - ULiège > Département des sciences de la vie > Génétique et biologie moléculaires animales
Struman, Ingrid  ;  Université de Liège - ULiège > Cancer-Molecular Angiogenesis Laboratory
Language :
English
Title :
Tumor microenvironment affects the composition of endothelial-derived exosomes: impact in tumor progression
Publication date :
13 September 2018
Number of pages :
1
Event name :
GIGA-CANCER DAY
Event organizer :
Pr Agnès NOEL
Event place :
Liège, Belgium
Event date :
13 Septembre 2018
Available on ORBi :
since 18 January 2019

Statistics


Number of views
72 (11 by ULiège)
Number of downloads
0 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi