Evaluation of a rapid-scanning quadrupole mass spectrometer in an apolar × ionic-liquid comprehensive two-dimensional gas chromatography system

Purcaro, Giorgia; Tranchida, P. Q.; Ragonese, C.; Conte, L.; Dugo, P.; Dugo, G.; Mondello, L.

doi:10.1021/ac101678r

Article (Scientific journals)

Evaluation of a rapid-scanning quadrupole mass spectrometer in an apolar × ionic-liquid comprehensive two-dimensional gas chromatography system

Purcaro, Giorgia; Tranchida, P. Q.; Ragonese, C. et al.

2010 • In Analytical Chemistry, 82 (20), p. 8583-8590

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/231069

DOI
10.1021/ac101678r

PubMed
20873720

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Keywords :

Acquisition rates; Column separation; Comprehensive two-dimensional gas chromatography; Fast acquisition; Ion monitoring; Mass spectra; Number of datum; Peak capacity; Quadrupole mass spectrometer; Quadrupole mass spectrometry; Rapid-scanning quadrupole mass spectrometer; Validated methods; Antigens; Liquid chromatography; Mass spectrometers; Mass spectrometry; Smoke detectors; Two dimensional; Gas chromatography; Allergens; Calibration; Gas Chromatography-Mass Spectrometry; Ions; Perfume; Reproducibility of Results; Time Factors

Abstract :

[en] Comprehensive two-dimensional gas chromatography (GC× GC) is a powerful technique which can enable a great increase in GC peak capacities. However, since secondary-column separations are very rapid, detectors with a fast acquisition rate are mandatory. Such a requirement has certainly limited the use of the quadrupole mass spectrometer in the GC× GC field. The present research is focused on the evaluation of a novel rapid-scanning quadrupole mass spectrometry (qMS) detector, characterized by a 20000 amu/s scan speed and a 50 Hz scan frequency, using a 290 amu mass range (40-330 m/z). The performance of the MS system was assessed by analyzing mixtures of 24 allergens, as well as a perfume sample, through GC× GC/qMS. The MS parameters evaluated at different acquisition rates (50, 33, and 25 Hz), as well as in the (simultaneous) scan/selected ion monitoring (SIM) mode, were the number of data points per peak, mass spectrum quality, peak skewing, and sensitivity. Two GC× GC/qMS methods, using the 50 Hz acquisition rate and the scan/SIM mode, were validated. Both methods provided similar results in terms of repeatability, accuracy, and linearity, while a great increase in sensitivity was observed (ca. a factor of 10) under scan/SIM conditions. The validated method proved to be suitable for the analysis of perfume allergens, according to the requirements of Directive 2003/15/EC. © 2010 American Chemical Society.

Disciplines :

Chemistry

Author, co-author :

Purcaro, Giorgia ; Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes

Tranchida, P. Q.; Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, viale Annunziata, 98168 Messina, Italy

Ragonese, C.; Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, viale Annunziata, 98168 Messina, Italy

Conte, L.; Dipartimento di Scienze Degli Alimenti, Università Degli Studi di Udine, via Sondrio 2, 33100 Udine, Italy

Dugo, P.; Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, viale Annunziata, 98168 Messina, Italy, Università Campus-Bio-medico, via Alvaro del Portillo 21, 00128 Roma, Italy

Dugo, G.; Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, viale Annunziata, 98168 Messina, Italy

Mondello, L.; Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, viale Annunziata, 98168 Messina, Italy, Università Campus-Bio-medico, via Alvaro del Portillo 21, 00128 Roma, Italy

Language :

English

Title :

Evaluation of a rapid-scanning quadrupole mass spectrometer in an apolar × ionic-liquid comprehensive two-dimensional gas chromatography system

Publication date :

2010

Journal title :

Analytical Chemistry

ISSN :

0003-2700

eISSN :

1520-6882

Publisher :

American Chemical Society, United States - District of Columbia

Volume :

Issue :

Pages :

8583-8590

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 10 January 2019

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