Ashcroft F.M., Rorsman P. (1989) Electrophysiology of the pancreatic β-cell. Prog Biophys Mol Biol 54:87-143.
Nichols C.G., Lederer W.J. (1991) Adenosine triphosphate-sensitive potassium channels in the cardiovascular system. Am J Physiol 261.
Quayle J.M., Nelson M.T., Standen N.B. (1997) ATP-sensitive and inwardly-rectifying potassium channels in smooth muscle. Physiol Rev 77:1165-1232.
Davis N.W., Standen N.B., Stanfield P.R. (1991) ATP-dependent potassium channels of muscle cells: Their properties, regulation, and possible functions. J Bioenerg Biomembr 23:509-535.
Liss B., Bruns R., Roeper J. (1999) Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. EMBO J 18:833-846.
Schmid-Anttomarchi H., Amoroso S., Fosset M., Lazdunski M. (1990) K+ channel openers activate brain sulphonylurea-sensitive K+ channels and block neurosecretion. Proc Natl Acad Sci U S A 87:3489-3492.
Heurteaux C., Bertaina V., Widmann C., Lazdunski M. (1993) K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein and amyloid-protien precursor genes and neuronal death in rat hippocampus. Proc Natl Acad Sci U S A 90:9431-9435.
Sakura H., Ämmälä C., Smith P.A., Gribble F.M., Ashcroft F.M. (1995) Cloning and functional expression of the cDNA encoding a novel ATP-sensitive potassium channel expressed in pancreatic β-cells, brain, heart and skeletal muscle. FEBS Lett 377:338-344.
Aguilar-Bryan L., Nichols C.G., Wechsler S.W., Clement J.P. IV, Boyd A.E., Gonzalez G., Herrera-Sosa H., Nguy K., Bryan J., Nelson D.A. (1995) Cloning of the β-cell high-affinity sulphonylurea receptor: A regulator of insulin secretion. Science 268:423-425.
Inagaki N., Gonoi T., Clement J.P. IV, Namba N., Inazawa J., Gonzalez G., Aguilar-Bryan L., Seino S., Bryan J. (1995) Reconstitution of IKATP channel: An inward rectifier subunit plus the sulphonylurea receptor. Science 270:1166-1169.
Inagaki N., Gonoi T., Clement J.P. IV, Wang C.Z., Aguilar-Bryan L., Bryan J., Seino S. (1996) A family of sulfonylurea receptors determines the properties of ATP-sensitive K+ channels. Neuron 16:1011-1017.
Inagaki N., Gonoi T., Seino S. (1997) Subunit stoichiometry of the pancreatic β-cell ATP-sensitive K+ channel. FEBS Lett 409:232-236.
Clement J.P. IV, Kuroilwar K., Gonzalez G., Schwanstecher M., Panten U., Aguilar-Bryan L., Bryan J. (1997) Association and stoichiometry of KATP channel subunits. Neuron 18:827-838.
Shyng S.-L., Nichols C.G. (1997) Octameric stochiometry of the KATP channel complex. J Gen Physiol 110:655-664.
Tucker S.J., Gribble F.M., Zhao C., Trapp S., Ashcroft F.M. (1997) Truncation of Kir6.2 produces ATP-sensitive K-channels in the absence of the sulphonylurea receptor. Nature 387:179-181.
Ashcroft F.M., Gribble F.M. (1998) Correlating structure and function in ATP-sensitive K+ channels. Trends Neurosci 21:288-294.
Isomoto S., Kondo C., Yamada M., Matsumoto S., Horio Y., Matsuzawa Y., Kurachi Y. (1996) A novel sulphonylurea receptor forms with BIR (Kir6.2) a smooth muscle type of ATP-sensitive K+ channel. J Biol Chem 271:24321-24325.
Yamada M., Isomoto S., Matsumoto S., Kondo C., Shindo T., Horio Y., Kurachi Y. (1997) Nucleotide sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel. J Physiol 499:715-720.
Karschin A., Brockhaus J., Ballanyi K. (1998) KATP channel formation by the sulphonylurea receptors SUR 1 with Kir6.2 subunits in rat dorsal vagal neurons in situ. J Physiol 509:339-346.
Zerangue N., Schwappach B., Jan Y.N., Jan L.Y. (1999) A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Neuron 22:537-548.
Terzic A., Jahangir A., Kurachi Y. (1995) Cardiac ATP-sensitive K+ channels: Regulation by intracellular nucleotides and K+ channel-opening drugs. Am J Physiol 269.
Fujita A., Kurachi Y. (2000) Molecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers. Pharmacol Ther 85:39-53.
Ashcroft F.M., Gribble F.M. (2000) New windows on the mechanism of action of K(ATP) channel openers. Trends Pharmacol Sci 21:439-445.
Shindo T., Yamada M., Isomoto S., Horio Y., Kurachi Y. (1998) SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil. Br J Pharmacol 124:985-991.
Moreau C., Jacquet H., Prost A.L., D'Hahan N., Vivaudou M. (2000) The molecular basis of the specificity of action of KATP channel openers. EMBO J 19:6644-6651.
Reimann F., Gribble F.M., Ashcroft F.M. (2000) Differential response of K(ATP) channels containing SUR 2A or SUR2B subunits to nucleotides and pinacidil. Mol Pharmacol 58:1318-1325.
D'Hahan N., Jacquet H., Moreau C., Catty P., Vivaudou M. (1999) A transmembrane domain of the sulfonylurea receptor mediates activation of ATP-sensitive K+ channels by K+ channel openers. Mol Pharm 56:308-315.
D'Hahan N., Moreau C., Prost A.-L., Jacquet H., Alekseev A.E., Terzic A., Vivaudou M. (1999) Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP. Proc Natl Acad Sci U S A 96:12162-12167.
Babenko A.P., Gonzalez G., Bryan J. (2000) Pharmaco-topology of sulfonylurea receptors: Separate domains of the regulatory subunits of K(ATP) channel isoforms are required for selective interaction with K(+) channel openers. J Biol Chem 275:717-720.
Matsuoka T., Matsushita K., Katayama Y., Fujita A., Inageda K., Tanemoto M., Inanobe A., Yamashita S., Matsuzawa Y., Kurachi Y. (2000) C-terminal tails of sulfonylurea receptors control ADP-induced activation and diazoxide modulation of ATP-sensitive K(+) channels. Circ Res 87:873-880.
Tanabe K., Tucker S.J., Matsuo M., Proks P., Ashcroft F.M., Seino S., Amachi T., Ueda K. (1999) Direct photoaffinity labeling of the Kir6.2 subunit of the ATP-sensitive K+ channel by 8-Azido-ATP. J Biol Chem 274:3931-3933.
Nichols C.G., Shyng S.L., Nestorowicz A., Glaser B., Clement J.P., Gonzalez G., Aguilar-Bryan L., Permutt M.A., Bryan J. (1996) Adenosine diphosphate as an intracellular regulator of insulin secretion. Science 272:1785-1787.
Gribble F.M., Tucker S.J., Ashcroft F.M. (1997) The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO J 16:1145-1152.
Gribble F.M., Tucker S.J., Haug T., Ashcroft F.M. (1998) MgATP acctivates the beta cell KATP channel by interaction with its SUR 1 subunit. Proc Natl Acad Sci U S A 95:7185-7190.
Shyng S., Ferrigni T., Nichols C.G. (1997) Regulation of KATP channel activity by diazoxide and MgADP: Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor. J Gen Physiol 110:643-654.
Kozlowski R.J., Hales C.N., Ashford M.L.J. (1989) Dual effects of diazoxide on ATP-K+ currents recorded from an insulin-secreting cell line. Br J Pharmacol 97:1039-1050.
Fan Z., Nakayama K., Hiraoka M. (1990) Multiple actions of pinacidil on adenosine triphosphate-sensitive potassium channels in guinea-pig ventricular myocytes. J Physiol 430:273-295.
Gribble F.M., Reimann F., Ashfield R., Ashcroft F.M. (2000) Nucleotide modulation of pinacidil stimulation of the cloned KATP channel Kir6.2/SUR 2A. Mol Pharm 57:1256-1261.
Hambrock A., Loffler W.C., Kurachi Y., Quast U. (1998) Mg2+ and ATP dependence of K(ATP) channel modulator binding to the recombinant sulphonylurea receptor SUR2B. Br J Pharmacol 125:577-583.
Schwanstecher M., Sieverding C., Dorschner H., Gross I., Aguilar-Bryan L., Schwanstecher C., Bryan J. (1998) Potassium channel openers require ATP to bind to and act through sulfonylurea receptors. EMBO J 17:5529-5535.
Bienengraeber M., Alekseev A.E., Abraham M.R., Carrasco A.J., Moreau C., Vivaudou M., Dzeja P.P., Terzic A. (2000) ATPase activity of the sulfonylurea receptor: A catalytic function for the KATP channel complex. FASEB J 14:1943-1952.
Björk E., Berne C., Kämpe O., Wibell L., Oskarsson P., Karlsson F. (1996) Diazoxide treatment at onset preserved residual insulin secretion in adults with autoimmne diabetes. Diabetes 45:1427-1430.
Björk E., Berne C., Karlsson F. (1998) Induction of beta-cell rest in type 1 diabetes: Studies on the effects of octreotide and diazoxide. Diabetes Care 21:427-430.
Karlsson F., Björk E. (1997) Beta-cell rest: A strategy for the prevention of autoimmune diabetes. Autoimmunity 26:117-122.
Aizawa T., Taguchi N., Sato Y., Nakabayashi T., Kobuchi H., Hikada H., Nagawasa T., Ishiara F., Ithoh N., Hashizume K. (1995) Prophylaxis of genetically determined diabetes by diazoxide: A study in a rat model of naturally occurring obese diabetes. J Pharmacol Exp Therp 275:194-199.
Hiramatsu S., Hoog A., Moller C., Grill V. (2000) Treatment with diazoxide causes prolonged improvement of beta-cell function in rat islets transplanted to a diabetic environment. Metabolism 49:657-661.
Alemzadeh R., Langley G., Upchurch L., Smith P., Slonim A.E. (1998) Beneficial effect of diazoxide in obese hyperinsulinemic adults. J Clin Endocrinol Metab 83:1911-1915.
Pirotte B., De Tullio P., Lebrun P., Antoine M.-H., Fontaine J., Masereel B., Schynts M., Dupont L., Herchuelz A., Delarge J. (1993) 3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: A new class of potassium channel openers?. J Med Chem 36:3211-3213.
De Tullio P., Pirotte B., Lebrun P., Fontaine J., Dupont L., Antoine M., Ouedraogo R., Khelili S., Maggetto C., Masereel B., Diouf O., Podona T., Delarge J. (1996) 3- and 4-substituted 4H-pyrido(4,3-e)-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: Synthesis, pharmacological evaluation, and structure-activity relationships. J Med Chem 39:937-948.
Lebrun P., Arkhammar P., Antoine M.-H., Nguyen Q.A., Bondo Hansen J., Pirotte B. (2000) A potent diazoxide analogue activating ATP-sensitive K+ channels and inhibiting insulin release. Diabetologia 43:723-732.
Pirotte B., Ouedraogo R., De Tullio P., Khelili S., Somers F., Boverie S., Dupont L., Fontaine J., Damas J., Lebrun P. (2000) 3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: Design, synthesis, and pharmacological evaluation. J Med Chem 43:1456-1466.
Ashfield R., Gribble F.M., Ashcroft S.J.H., Ashcroft F.M. (1999) Identification of the high-affinity tolbutamide site on the SUR1 subunit of the KATP channel. Diabetes 48:1341-1347.
Gribble F.M., Ashfield R., Ämmälä C., Ashcroft F.M. (1997) Properties of cloned ATP-sensitive K-currents expressed in Xenopus oocytes. J Physiol 498:87-98.
Gribble F.M., Tucker S.J., Ashcroft F.M. (1997) The interaction of nucleotides with the tolbutamide block of K-ATP currents: A reinterpretation. J Physiol 504:35-45.
Larsson O., Ämmälä C., Bokvist K., Fredholm B., Rorsman P. (1993) Stimulation of the KATP channel by ADP and diazoxide requires nucleotide hydrolysis in mouse pancreatic β-cells. J Physiol 463:349-365.
Gross I., Toman A., Uhde I., Schwanstecher C., Schwanstecher M. (1999) Stoichiometry of potassium channel opener action. Mol Pharm 56:1370-1373.
Uhde I., Toman A., Gross I., Schwanstecher C., Schwanstecher M. (1999) Indentification of the potassium channel opener site on sulfonylurea receptors. J Biol Chem 274:28079-28082.
Schwanstecher M., Brandt C., Behrends S., Schaupp U., Panten U. (1992) Effect of MgATP on pinacidil-induced displacement of glibenclamide from the sulphonylurea receptor in a pancreatic beta-cell line and rat cerebral cortex. Br J Pharmacol 106:295-301.
Ämmälä C., Moorhouse A., Ashcroft F.M. (1996) The sulphonylurea receptor confers diazoxide sensitivity on the inwardly-rectifying K-channel, Kir 6.1. J Physiol 494:709-714.
Carson M.R., Travis S.M., Welsh M.J. (1995) The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity. J Biol Chem 270:1711-1717.
Ko Y.H., Pedersen P.L. (1995) The first nucleotide binding fold of the cystic fibrosis transmembrane conductance regulator can function as an active ATPase. J Biol Chem 270:22093-22096.
Ueda K., Komine J., Matsuo M., Seino S., Amachi T. (1999) Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide. Proc Natl Acad Sci U S A 96:1268-1272.
Matsuo M., Tanabe K., Kioka N., Amachi T., Ueda K. (2000) Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR 2A, and SUR2B. J Biol Chem 275:28757-28763.
Tusnady G.E., Bakos E., Varadi A., Sarkadi B. (1997) Membrane topology distinguishes a subfamily of the ATP-binding cassette (ABC) transporters. FEBS Lett 402:1-3.
Raab-Graham K.F., Cirilo L.J., Boettcher A.A., Radeke C.M., Vandenberg C.A. (1999) Membrane topology of the amino-terminal region of the sulfonylurea receptor. J Biol Chem 274:29122-29129.
