Article (Scientific journals)
Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study
Forster, C.; VANHAUDENHUYSE, Audrey; GAST, Pierrette et al.
2018In British Journal of Anaesthesia, 121 (5), p. 1059-1064
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Keywords :
adverse effects; anaesthetic i.v.; local anaesthetic; outcomes; pain; postoperative
Abstract :
[en] Background: Propofol use during sedation for colonoscopy can result in cardiopulmonary complications. Intravenous lidocaine can alleviate visceral pain and decrease propofol requirements during surgery. We tested the hypothesis that i.v. lidocaine reduces propofol requirements during colonoscopy and improves post-colonoscopy recovery. Methods: Forty patients undergoing colonoscopy were included in this randomised placebo-controlled study. After titration of propofol to produce unconsciousness, patients were given i.v. lidocaine (1.5 mg kg−1 then 4 mg kg−1 h−1) or the same volume of saline. Sedation was standardised and combined propofol and ketamine. The primary endpoint was propofol requirements. Secondary endpoints were: number of oxygen desaturation episodes, endoscopists’ working conditions, discharge time to the recovery room, post-colonoscopy pain, fatigue. Results: Lidocaine infusion resulted in a significant reduction in propofol requirements: 58 (47) vs 121 (109) mg (P=0.02). Doses of ketamine were similar in the two groups: 19 (2) vs 20 (3) mg in the lidocaine and saline groups, respectively. Number of episodes of oxygen desaturation, endoscopists’ comfort, and times for discharge to the recovery room were similar in both groups. Post-colonoscopy pain (P<0.01) and fatigue (P=0.03) were significantly lower in the lidocaine group. Conclusions: Intravenous infusion of lidocaine resulted in a 50% reduction in propofol dose requirements during colonoscopy. Immediate post-colonoscopy pain and fatigue were also improved by lidocaine. Clinical trial registration: NCT 02784860. © 2018 British Journal of Anaesthesia
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Forster, C.;  Department of Anaesthesiology, CHU Liège, University of Liège, Domaine du Sart Tilman, Liège, Belgium
VANHAUDENHUYSE, Audrey  ;  Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Centre interdisciplinaire d'algologie
GAST, Pierrette ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de gastroentérologie, hépatologie, onco. digestive
Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
HICK, Gaëtane ;  Centre Hospitalier Universitaire de Liège - CHU > Département d'Anesthésie et réanimation > Service d'anesthésie - réanimation
Brichant, Jean-François ;  Université de Liège - ULiège > Département des sciences cliniques > Anesthésie et réanimation
Joris, Jean ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Language :
English
Title :
Intravenous infusion of lidocaine significantly reduces propofol dose for colonoscopy: a randomised placebo-controlled study
Publication date :
2018
Journal title :
British Journal of Anaesthesia
ISSN :
0007-0912
eISSN :
1471-6771
Publisher :
Elsevier Ltd
Volume :
121
Issue :
5
Pages :
1059-1064
Peer reviewed :
Peer Reviewed verified by ORBi
Additional URL :
Funders :
AbbVie [BE]
AstraZeneca [BE]
Abbott Laboratories [US-IL] [US-IL]
Pfizer [AU]
E.L. Wiegand Foundation [US-NV] [US-NV]
Celgene [US-NJ] [US-NJ]
Mitsubishi Tanabe Pharma Corporation [JP]
Chiesi Farmaceutici Spa [IT]
MSD - Meso Scale Diagnostics [US-MD] [US-MD]
Takeda Oncology
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since 28 December 2018

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