Article (Scientific journals)
Pluripotent stem cell-derived cochlear cells: a challenge in constant progress
Czajkowski, Amandine; Mounier, Anaïs; Delacroix, Laurence et al.
2019In Cellular and Molecular Life Sciences
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Keywords :
Stem cells; Hair cells; inner ear
Abstract :
[en] Hearing loss is a common affection mainly resulting from irreversible loss of the sensory hair cells of the cochlea; therefore, developing therapies to replace missing hair cells is essential. Understanding the mechanisms that drive their formation will not only help to unravel the molecular basis of deafness, but also give a roadmap for recapitulating hair cells development from cultured pluripotent stem cells. In this review, we provide an overview of the molecular mechanisms involved in hair cell production from both human and mouse embryonic stem cells. We then provide insights how this knowledge has been applied to differentiate induced pluripotent stem cells into otic progenitors and hair cells. Finally, we discuss the current limitations for properly obtaining functional hair cell in a Petri dish, as well as the difficulties that have to be overcome prior to consider stem cell therapy as a potential treatment for hearing loss.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Czajkowski, Amandine ;  Université de Liège - ULiège > GIGA - Neurosciences
Mounier, Anaïs ;  Université de Liège - ULiège > GIGA - Neurosciences
Delacroix, Laurence ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Malgrange, Brigitte  ;  Université de Liège - ULiège > GIGA - Neurosciences
Language :
English
Title :
Pluripotent stem cell-derived cochlear cells: a challenge in constant progress
Publication date :
2019
Journal title :
Cellular and Molecular Life Sciences
ISSN :
1420-682X
eISSN :
1420-9071
Publisher :
Birkhauser Verlag, Switzerland
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 22 December 2018

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