Article (Scientific journals)
Sécurité cardiovasculaire des inhibiteurs de la DPP-4 comparée à celle des sulfamides hypoglycémiants
Scheen, André
2018In Revue Médicale Suisse, 14 (615), p. 1468-1472
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Abstract :
[en] After metformin monotherapy, the choice between a sulfonylurea and a dipeptidyl peptidase-4 (DPP-4) inhibitor may be critical in clinical practice. This article compares the cardiovascular safety of these two pharmacological classes based on meta-analyses of randomized controlled trials and observational studies. Both approaches show a better cardiovascular safety with DPP-4 inhibitors than with sulfonylureas. However, some heterogeneity exists, most probably explained by differences between the molecules, especially among sulfonylureas as those of last generation (more particularly gliclazide) seem to have a better safety profile. The ongoing head-to-head prospective trial CAROLINA compares the cardiovascular safety of glimepiride and linagliptin in high-risk patients, with results expected in 2019. © 2018 Editions Medecine et Hygiene. All rights reserved.
Disciplines :
Cardiovascular & respiratory systems
Pharmacy, pharmacology & toxicology
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Title :
Sécurité cardiovasculaire des inhibiteurs de la DPP-4 comparée à celle des sulfamides hypoglycémiants
Alternative titles :
[en] Cardiovascular safety of DPP-4 inhibitors compared to that of sulfonylureas
Publication date :
2018
Journal title :
Revue Médicale Suisse
ISSN :
1660-9379
Publisher :
Editions Medecine et Hygiene
Volume :
14
Issue :
615
Pages :
1468-1472
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 03 December 2018

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