Article (Scientific journals)
Efficacy of switching to infliximab in patients with Crohn's disease with loss of response to adalimumab.
Peeters, H.; Louis, Edouard; Baert, F. et al.
2018 • In Acta Gastro-Enterologica Belgica, 81 (1), p. 15-21
 

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Keywords :
Adalimumab/therapeutic use; Adult; Aged; Belgium; Crohn Disease/drug therapy; Female; Gastrointestinal Agents/therapeutic use; Humans; Infliximab/therapeutic use; Male; Middle Aged; Prospective Studies; Treatment Outcome; Crohn's disease; adalimumab; infliximab; switching
Abstract :
[en] BACKGROUND AND STUDY AIMS: Anti-TNF monoclonal antibodies are a cornerstone in the treatment of Crohn's disease. Prospective data on switching from the subcutaneous and human adalimumab (ADM) to the intravenous and chimeric infliximab (IFX) are scarce. PATIENTS AND METHODS: In this prospective, observational, multicentre cohort study we included 21 patients with loss of response to ADM despite at least 4 consecutive weekly injections. Clinical response (CDAI drop>/=70 points) and remission (CDAI
Disciplines :
Gastroenterology & hepatology
Author, co-author :
Peeters, H.
Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
Baert, F.
Dewit, O.
Coche, J. C.
Ferrante, M.
Lambrecht, G.
Colard, A.
Van Gossum, A.
Bossuyt, P.
Moreels, T.
Vander Cruyssen, B.
Gils, A.
De Vos, M.
Language :
English
Title :
Efficacy of switching to infliximab in patients with Crohn's disease with loss of response to adalimumab.
Publication date :
2018
Journal title :
Acta Gastro-Enterologica Belgica
ISSN :
0001-5644
eISSN :
1784-3227
Publisher :
Acta Medica Belgica, Bruxelles, Belgium
Volume :
81
Issue :
1
Pages :
15-21
Funders :
AbbVie
Commentary :
(c) Acta Gastro-Enterologica Belgica.
Available on ORBi :
since 02 December 2018

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