The precuneus may encode irrationality in human gambling

[en] Humans often make irrational decisions, especially psychiatric patients who have dysfunctional cognitive and emotional circuitry. Understanding the neural basis of decision-making is therefore essential towards patient management, yet current studies suffer from several limitations. Functional magnetic resonance imaging (fMRI) studies in humans have dominated decision-making neuroscience, but have poor temporal resolution and the blood oxygenation level-dependent signal is only a proxy for neural activity. On the other hand, lesion studies in humans used to infer functionality in decision-making lack characterization of neural activity altogether. Using a combination of local field potential recordings in human subjects performing a financial decision-making task, spectral analyses, and non-parametric cluster statistics, we analyzed the activity in the precuneus. In nine subjects, the neural activity modulated significantly between rational and irrational trials in the precuneus (p < 0.001). In particular, high-frequency activity (70-100 Hz) increased when irrational decisions were made. Although preliminary, these results suggest suppression of gamma rhythms via electrical stimulation in the precuneus as a therapeutic intervention for pathological decision-making.

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Sacré, Pierre ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Robotique intelligente

Kerr, Matthew S. D.

Subramanian, Sandya

Kahn, Kevin

Gonzalez-Martinez, Jorge

Johnson, Mathew A.

Sarma, Sridevi V.

Gale, John T.

Language :

English

Title :

The precuneus may encode irrationality in human gambling

Publication date :

2016

Event name :

38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Event organizer :

IEEE

Event place :

Orlando, United States - Florida

Event date :

from 16-08-2016 to 20-08-2016

Audience :

International

Main work title :

Proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

Publisher :

IEEE

Peer reviewed :

Peer reviewed

Available on ORBi :

since 26 November 2018

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Bibliography

M. Toda, "Emotion and decision making," Acta Psychologica, vol. 45, no. 1-3, pp. 133-155, 1980
A. Bechara, "The role of emotion in decision-making: Evidence from neurological patients with orbitofrontal damage," Brain and Cognition, vol. 55, no. 1, pp. 30-40, 2004
J. Kim and M. E. Ragozzino, "The involvement of the orbitofrontal cortex in learning under changing task contingencies," Neurobiology of Learning and Memory, vol. 83, no. 2, pp. 125-133, 2005
I. Bohn, C. Giertler, and W. Hauber, "Orbital prefrontal cortex and guidance of instrumental behaviour in rats under reversal conditions," Behavioural Brain Research, vol. 143, no. 1, pp. 49-56, 2003
N. K. Logothetis, "What we can do and what we cannot do with fMRI," Nature, vol. 453, pp. 869-878, June 2008
G. I. Christopoulos, P. N. Tobler, P. Bossaerts, R. J. Dolan, and W. Schultz, "Neural correlates of value, risk, and risk aversion contributing to decision making under risk," The Journal of Neuroscience, vol. 29, no. 40, pp. 12574-12583, 2009
M. A. Johnson, S. Thompson, J. Gonzalez-Martinez, H.-J. Park, J. Bulacio, I. Najm, K. Kahn, M. Kerr, S. V. Sarma, and J. T. Gale, "Performing behavioral tasks in subjects with intracranial electrodes," Journal of Visualized Experiments, no. 92, p. e51947, 2014
D. Ongür and J. Price, "The organization of networks within the orbital and medial prefrontal cortex of rats, monkeys and humans," Cerebral Cortex, vol. 10, no. 3, pp. 206-219, 2000
W. F. Asaad and E. N. Eskandar, "A flexible software tool for temporally-precise behavioral control in Matlab," Journal of Neuroscience Methods, vol. 174, no. 2, pp. 245-258, 2008
J. Gonzalez-Martinez, J. Mullin, S. Vadera, J. Bulacio, G. Hughes, S. Jones, R. Enatsu, and I. Najm, "Stereotactic placement of depth electrodes in medically intractable epilepsy," Journal of Neurosurgery, vol. 120, no. 3, pp. 639-644, 2014
F. Cardinale and G. Lo Russo, "Stereo-electroencephalography safety and effectiveness: Some more reasons in favor of epilepsy surgery," Epilepsia, vol. 54, no. 8, pp. 1505-1506, 2013
E. Maris and R. Oostenveld, "Nonparametric statistical testing of EEGand MEG-data," Journal of Neuroscience Methods, vol. 164, no. 1, pp. 177-190, 2007
H. Bokil, P. Andrews, J. E. Kulkarni, S. Mehta, and P. P. Mitra, "Chronux: A platform for analyzing neural signals," Journal of Neuroscience Methods, vol. 192, no. 1, pp. 146-151, 2010
T. Ossandón, K. Jerbi, J. R. Vidal, D. J. Bayle, M.-A. Henaff, J. Jung, L. Minotti, O. Bertrand, P. Kahane, and J.-P. Lachaux, "Transient suppression of broadband gamma power in the default-mode network is correlated with task complexity and subject performance," The Journal of Neuroscience, vol. 31, no. 41, pp. 14521-14530, 2011
M. Schaefer, H.-J. Heinze, M. Rotte, and C. Denke, "Communicative versus strategic rationality: Habermas theory of communicative action and the social brain," PLoS ONE, vol. 8, p. e65111, May 2013
T. McCarthy, "Translator's introduction," in The theory of communicative action: Reason and the Rationalization of Society (J. Habermas, ed.), Beacon Press, 1984.