[en] Humans often make irrational decisions, especially psychiatric patients who have dysfunctional cognitive and emotional circuitry. Understanding the neural basis of decision-making is therefore essential towards patient management, yet current studies suffer from several limitations. Functional magnetic resonance imaging (fMRI) studies in humans have dominated decision-making neuroscience, but have poor temporal resolution and the blood oxygenation level-dependent signal is only a proxy for neural activity. On the other hand, lesion studies in humans used to infer functionality in decision-making lack characterization of neural activity altogether. Using a combination of local field potential recordings in human subjects performing a financial decision-making task, spectral analyses, and non-parametric cluster statistics, we analyzed the activity in the precuneus. In nine subjects, the neural activity modulated significantly between rational and irrational trials in the precuneus (p < 0.001). In particular, high-frequency activity (70-100 Hz) increased when irrational decisions were made. Although preliminary, these results suggest suppression of gamma rhythms via electrical stimulation in the precuneus as a therapeutic intervention for pathological decision-making.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Sacré, Pierre ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Robotique intelligente
Kerr, Matthew S. D.
Subramanian, Sandya
Kahn, Kevin
Gonzalez-Martinez, Jorge
Johnson, Mathew A.
Sarma, Sridevi V.
Gale, John T.
Language :
English
Title :
The precuneus may encode irrationality in human gambling
Publication date :
2016
Event name :
38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Event organizer :
IEEE
Event place :
Orlando, United States - Florida
Event date :
from 16-08-2016 to 20-08-2016
Audience :
International
Main work title :
Proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
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