Persistent organic pollutants; exposure; blubber; metabolic profiles; gray seal pups
Abstract :
[en] ersistent organic pollutants (POPs) are toxic, ubiq-
uitous, resist breakdown, bioaccumulate in living tissue, and biomagnify
in food webs. POPs can also alter energy balance in humans and wildlife.
Marine mammals experience high POP concentrations, but consequen-
ces for their tissue metabolic characteristics are unknown. We used
blubber explants from wild, gray seal (Halichoerus grypus) pups to
examine impacts of intrinsic tissue POP burden and acute experimental
POP exposure on adipose metabolic characteristics. Glucose use, lactate
production, and lipolytic rate differed between matched inner and outer
blubber explants from the same individuals and between feeding and
natural fasting. Glucose use decreased with blubber dioxin-like PCBs
(DL-PCB) and increased with acute experimental POP exposure.
Lactate production increased with DL-PCBs during feeding, but decreased with DL-PCBs during fasting. Lipolytic rate increased with blubber dichlorodiphenyltrichloroethane and its metabolites (DDX) in fasting animals, but declined with DDX when animals were feeding. Our data show that POP burdens are high enough in seal pups to alter adipose function early in life, when fat deposition and mobilization are vital. Such POP-induced alterations to adipose metabolic properties may significantly alter energy balance regulation in marine top predators, with the potential for long-term impacts on fitness and survival.
Research center :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège MolSys - Molecular Systems - ULiège
Disciplines :
Chemistry
Author, co-author :
Robinson, Kelly
Hall, Ailsa
Debier, Cathy
Eppe, Gauthier ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie analytique inorganique
Thomé, Jean-Pierre ; Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Ecologie animale et écotoxicologie
Bennett, Kimberley
Language :
English
Title :
Persistent Organic Pollutant Burden, Experimental POP Exposure, and Tissue Properties Affect Metabolic Profiles of Blubber from Gray Seal Pups
Publication date :
2018
Journal title :
Environmental Science and Technology
ISSN :
0013-936X
eISSN :
1520-5851
Publisher :
American Chemical Society, United States - District of Columbia
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