Article (Scientific journals)
Maternal helminth infections and the shaping of offspring immunity.
Dewals, Benjamin G; Layland, Laura E.; Prazeres da Costa, Clarissa et al.
2018In Parasite Immunology, p. 12599
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Abstract :
[en] Helminth infections leave a long lasting immunological footprint on their hosts. Clinical studies have provided first evidence that maternal helminth infections can result in an altered immune profile in their offspring which can potentially shape how they respond to conditions throughout life. This can relate to changes in offspring induction of immune responses against other diseases. However, if these changes result in actual changes in offspring ability to control disease is unclear. Our understanding of which immune mechanisms are altered and how they are changed is limited. In this review, we highlight what we know from human and mouse studies about this important context of helminth exposure. Moreover, we discuss how mechanisms such as antibody transfer, antigen exposure, maternal cell uptake, chimerism and epigenetics are all likely to be functional contributors to the striking changes that are seen in offspring born or nursed by helminth exposed mothers. This article is protected by copyright. All rights reserved.
Disciplines :
Immunology & infectious disease
Author, co-author :
Dewals, Benjamin G  ;  Université de Liège - ULiège > Immunologie et vaccinologie
Layland, Laura E.
Prazeres da Costa, Clarissa
Horsnell, William G.
Language :
English
Title :
Maternal helminth infections and the shaping of offspring immunity.
Publication date :
2018
Journal title :
Parasite Immunology
ISSN :
0141-9838
eISSN :
1365-3024
Publisher :
Blackwell, Oxford, United Kingdom
Pages :
e12599
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
This article is protected by copyright. All rights reserved.
Available on ORBi :
since 03 November 2018

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