Reference : Perinatal short-chain fructooligosaccharides program intestinal microbiota and improv...
Scientific journals : Article
Life sciences : Microbiology
http://hdl.handle.net/2268/228478
Perinatal short-chain fructooligosaccharides program intestinal microbiota and improve enteroinsular axis function and inflammatory status in high-fat diet-fed adult pigs.
English
Le Bourgot, Cindy [> >]
Ferret-Bernard, Stephanie [> >]
Apper, Emmanuelle [> >]
Taminiau, Bernard mailto [Université de Liège - ULiège > Département de sciences des denrées alimentaires (DDA) > Microbiologie des denrées alimentaires >]
Cahu, Armelle [> >]
Le Normand, Laurence [> >]
Respondek, Frederique [> >]
Le Huerou-Luron, Isabelle [> >]
Blat, Sophie [> >]
2018
FASEB Journal
fj201800108R
Yes (verified by ORBi)
International
0892-6638
1530-6860
United States
[en] GLP-1 ; Prevotella ; nutritional programming ; prebiotic
[en] Perinatal nutrition programs physiologic and metabolic functions, with consequences on the susceptibility to develop metabolic diseases in adulthood. The microbiota represents a key factor of such programming. We investigated whether perinatal prebiotic [short-chain fructooligosaccharides (scFOS)] supplementation improved adult metabolic health in association with microbiota changes in pigs used as human model. Sows were supplemented with scFOS or not during the end of gestation and the entire lactation, and offspring received scFOS accordingly during 1 mo after weaning. Pigs were then fed a standard diet for 5 mo, followed by a high-fat diet for 3 mo once adults. Perinatal scFOS supplementation induced a persistent modulation of the composition of the fecal microbiota in adulthood, notably by increasing the Prevotella genus. Meanwhile, scFOS animals displayed improved capacity to secrete glucagon-like peptide-1 and improved pancreas sensitivity to glucose without any changes in peripheral insulin sensitivity. Perinatal scFOS supplementation also increased ileal secretory IgA secretion and alkaline phosphatase activity and decreased TNF-alpha expression in adipose tissue. In conclusion, perinatal scFOS supplementation induced long-lasting modulation of intestinal microbiota and had beneficial consequences on the host physiology in adulthood. Our results highlight the key role of perinatal nutrition on later microbiota and host metabolic adaptation to an unbalanced diet.-Le Bourgot, C., Ferret-Bernard, S., Apper, E., Taminiau, B., Cahu, A., Le Normand, L., Respondek, F., Le Huerou-Luron, I., Blat, S. Perinatal short-chain fructooligosaccharides program intestinal microbiota and improve enteroinsular axis function and inflammatory status in high-fat diet-fed adult pigs.
http://hdl.handle.net/2268/228478
10.1096/fj.201800108R

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