1, 25 dihydroxyvitamin D; 25 hydroxyvitamin D; Vitamin D Metabolism Ratio (VMR); standardization
Abstract :
[en] Total 25-hydroxyvitamin D is currently considered as the most representative metabolite of vitamin D status. There are a multitude of challenges that still deserve to be addressed and despite recent technological advances its determination remains complicated. This current review gives an abbreviated overview of the phases of development that vitamin D metabolite determination has gone through and discusses the difficulties that still require resolving. Furthermore, given the different platforms and methodologies available, the critical issue of standardization and all efforts made as far towards its realization have been discussed. And last but not least, the concepts of 'free' and 'bioavailable' vitamin D along with the 'Vitamin D Metabolism Ratio' have been discussed.
Disciplines :
Laboratory medicine & medical technology
Author, co-author :
Cavalier, Etienne ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Souberbielle, Jean-Claude
Language :
English
Title :
Vitamin D and its metabolites: from now and beyond.
Publication date :
2018
Journal title :
eJIFCC: Electronic journal of the International Federation of Clinical Chemistry and Laboratory Medicine
eISSN :
1650-3414
Publisher :
International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), Milano, Italy
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