Article (Scientific journals)
Oxidative stress in chronic kidney disease
Daenen, K.; Andries, A.; Mekahli, D. et al.
2019In Pediatric Nephrology
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Keywords :
Antioxidants; Cardiovascular disease; Chronic kidney disease; Oxidative stress
Abstract :
[en] Oxidative stress (OS), defined as disturbances in the pro-/antioxidant balance, is harmful to cells due to the excessive generation of highly reactive oxygen (ROS) and nitrogen (RNS) species. When the balance is not disturbed, OS has a role in physiological adaptations and signal transduction. However, an excessive amount of ROS and RNS results in the oxidation of biological molecules such as lipids, proteins, and DNA. Oxidative stress has been reported in kidney disease, due to both antioxidant depletions as well as increased ROS production. The kidney is a highly metabolic organ, rich in oxidation reactions in mitochondria, which makes it vulnerable to damage caused by OS, and several studies have shown that OS can accelerate kidney disease progression. Also, in patients at advanced stages of chronic kidney disease (CKD), increased OS is associated with complications such as hypertension, atherosclerosis, inflammation, and anemia. In this review, we aim to describe OS and its influence on CKD progression and its complications. We also discuss the potential role of various antioxidants and pharmacological agents, which may represent potential therapeutic targets to reduce OS in both pediatric and adult CKD patients. © 2018, IPNA.
Disciplines :
Urology & nephrology
Author, co-author :
Daenen, K.;  Department of Microbiology and Immunology, Laboratory of Nephrology, KU Leuven – University of Leuven, Leuven, 3000, Belgium, Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Leuven, 3000, Belgium, Department of Nephrology, Sahlgrenska University Hospital, Gothenburg, Sweden
Andries, A.;  Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven – University of Leuven, Leuven, 3000, Belgium
Mekahli, D.;  Department of Development and Regeneration, Laboratory of Pediatrics, PKD Group, KU Leuven – University of Leuven, Leuven, 3000, Belgium, Department of Pediatric Nephrology, University Hospitals Leuven, Leuven, 3000, Belgium
Van Schepdael, A.;  Department of Pharmaceutical and Pharmacological Sciences, Pharmaceutical Analysis, KU Leuven – University of Leuven, Leuven, 3000, Belgium
Jouret, François  ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Bammens, B.;  Department of Microbiology and Immunology, Laboratory of Nephrology, KU Leuven – University of Leuven, Leuven, 3000, Belgium, Department of Nephrology, Dialysis and Renal Transplantation, University Hospitals Leuven, Leuven, 3000, Belgium
Language :
English
Title :
Oxidative stress in chronic kidney disease
Publication date :
2019
Journal title :
Pediatric Nephrology
ISSN :
0931-041X
eISSN :
1432-198X
Publisher :
Springer Verlag
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 17 September 2018

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