Cord blood; Obstetric factors; Total nucleated cells; Placental unit volume; Hematopoietic stem cell transplantation
Abstract :
[en] Objectives. – There is a correlation between the success of the cord blood transplant and the numbers of
HSC found in the unit of cord blood donation. The purpose of this analysis is to identify obstetric factors
that may influence the quality of a cord blood unit taken during delivery.
Methods. – A retrospective study was carried out at the Lie`ge cord blood bank on a sample of 7.463 cord
blood units collected between 2000 and 2016. Eight obstetric factors were analyzed in relation to two
dependent variables; the total nucleated cells (TNC) and the volume of one unit of cord blood. The Welch
test, the percentiles 25 and 75 and the non-parametric Mann-Whitney Wilcoxon test were used.
Results. – Several obstetric parameters were found to influence (P < 0.05) the quality of the cord blood
unit are: cord clamping (> 15 seconds), the use of oxytocin during labor, a more advanced gestational
age (38–41 weeks), a higher birth weight (> 3300 gr), and a higher weight of the placenta (> 500 gr). A female newborn and the use of epidural, influence (P < 0.05) the number of TNC but not the volume of
the cord blood unit.
Conclusion. – We can conclude that the birth weight, the weight of the placenta, the gestational age and
cord clamping are parameters that could be used by maternity hospitals to identify births that enable
more voluminous grafts which are richer in total nucleated cells.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
de Jamblinne, Ysaline; Université Libre de Bruxelles - ULB > Ecole de Santé Publique > Centre de recherche Epide´miologie, biostatistique et recherche clinique
BAUDOUX, Etienne ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Laboratoire de thérapie cellulaire et génique (LTCG)
Delo, C; Université Libre de Bruxelles - ULB > Ecole de Santé Publique
Coppieters, Yves; Université Libre de Bruxelles - ULB > Ecole de Santé Publique > Centre de recherche Epidémiologie, biostatistique et recherche clinique,
Language :
French
Title :
Influence de facteurs obstétricaux sur les caractéristiques des greffons de sang de cordon ombilical
Alternative titles :
[en] Influence of obstetric factors on characteristics of umbilical cord blood transplants
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