[en] INTRODUCTION: Coronary angiography is commonly performed following non-ST segment elevation myocardial infarction (NSTEMI) to assess the need for revascularization. Some of these patients have myocardial infarction (MI) with no obstructive coronary atherosclerosis (MINOCA). Patients without severe obstructive lesions are usually treated conservatively. However, coronary angiography has known limitations in the assessment of lesion severity. We report our experience of using coronary Optical Coherence Tomography (OCT) in a series of patients without severe obstructive coronary lesions. METHODS: 165 patients underwent coronary OCT at Vancouver General Hospital. NSTEMI was the clinical presentation in 70 patients and 26 had angiographically intermediate lesions with 40%-69% diameter stenosis. Prior to OCT image acquisition, intracoronary nitroglycerin 100-200mug was administered. Blood in the vessel was displaced using contrast media by manual injections. RESULTS: OCT of the angiographically intermediate lesions showed larger minimal luminal area (MLA) than the angiographically severe lesions (MLA 3.3mm(2)+/-1.8mm(2) vs. 1.6mm(2)+/-0.6mm(2), p<0.001) and less severe % lumen area stenosis (54.2%+/-11.4% vs. 70.9%+/-6.8%, p=0.001). Plaque rupture or intracoronary thrombus was detected in 8/26 (31%) patients. PCI with stent deployment was performed in 16 patients (62%). CONCLUSION: In stabilized patients with NSTEMI and angiographically intermediate disease, OCT examination confirmed the lack of severe anatomical stenosis in most patients. However, OCT also identified coronary lesions with unstable features. Further research is needed to help guide management of this subgroup of patients.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
Bogale, Nigussie
LEMPEREUR, Mathieu ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Cardiologie interventionnelle
Sheikh, Imran
Wood, David
Saw, Jacqueline
Fung, Anthony
Language :
English
Title :
Optical coherence tomography (OCT) evaluation of intermediate coronary lesions in patients with NSTEMI.
Publication date :
2016
Journal title :
Cardiovascular Revascularization Medicine: including Molecular Interventions
ISSN :
1553-8389
eISSN :
1878-0938
Publisher :
Elsevier, New York, United States - New York
Volume :
17
Issue :
2
Pages :
113-8
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2016 Elsevier Inc. All rights reserved.
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