Burr, D. B. The importance of subchondral bone in osteoarthrosis. Curr Opin Rheumatol 10, 256–262 (1998)
Burr, D. B. The importance of subchondral bone in the progression of osteoarthritis. J Rheumatol Suppl 70, 77–80 (2004)
Bobinac, D., Spanjol, J., Zoricic, S. & Maric, I. Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans. Bone 32, 284–290 (2003)
Brown, T. D., Radin, E. L., Martin, R. B. & Burr, D. B. Finite element studies of some juxtarticular stress changes due to localized subchondral stiffening. Journal of biomechanics 17, 11–24 (1984)
Brandt, K. D., Dieppe, P. & Radin, E. L. Etiopathogenesis of osteoarthritis. Rheum Dis Clin North Am 34, 531–559 (2008)
Ding, M., Danielsen, C. C. & Hvid, I. Bone density does not reflect mechanical properties in early-stage arthrosis. Acta Orthop Scand 72, 181–185 (2001)
Ding, M., Dalstra, M., Linde, F. & Hvid, I. Changes in the stiffness of the human tibial cartilage-bone complex in early-stage osteoarthrosis. Acta Orthop Scand 69, 358–362 (1998)
Li, B. & Aspden, R. M. Composition and mechanical properties of cancellous bone from the femoral head of patients with osteoporosis or osteoarthritis. Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 12, 641–651 (1997)
Zysset, P. K., Sonny, M. & Hayes, W. C. Morphology-mechanical property relations in trabecular bone of the osteoarthritic proximal tibia. J Arthroplasty 9, 203–216 (1994)
Day, J. S. et al. A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res 19, 914–918 (2001)
Coats, A. M., Zioupos, P. & Aspden, R. M. Material properties of subchondral bone from patients with osteoporosis or osteoarthritis by microindentation testing and electron probe microanalysis. Calcif Tissue Int 73, 66–71 (2003)
Dall’Ara, E., Ohman, C., Baleani, M. & Viceconti, M. Reduced tissue hardness of trabecular bone is associated with severe osteoarthritis. J Biomech 44, 1593–1598 (2011)
Burr, D. B. & Radin, E. L. Microfractures and microcracks in subchondral bone: are they relevant to osteoarthrosis? Rheum Dis Clin N Am 29, 675-+ (2003)
Boyd, S. K., Muller, R. & Zernicke, R. F. Mechanical and architectural bone adaptation in early stage experimental osteoarthritis. J Bone Miner Res 17, 687–694 (2002)
Bjurholm, A., Kreicbergs, A., Brodin, E. & Schultzberg, M. Substance P- and CGRP-immunoreactive nerves in bone. Peptides 9, 165–171 (1988)
Buma, P. Innervation of the patella. An immunohistochemical study in mice. Acta Orthop Scand 65, 80–86 (1994)
Farrokhi, S., Keyak, J. H. & Powers, C. M. Individuals with patellofemoral pain exhibit greater patellofemoral joint stress: a finite element analysis study. Osteoarthritis and Cartilage 19, 287–294 (2011)
Burnett, W. D. et al. Knee osteoarthritis patients with severe nocturnal pain have altered proximal tibial subchondral bone mineral density. Osteoarthritis Cartilage 23, 1483–1490 (2015)
Burnett, W. D. et al. Patella Bone Density Is Lower in Knee Osteoarthritis Patients Experiencing Pain at Rest. Osteoarthritis and Cartilage 20, S200–S201 (2012)
Burnett, W. D. et al. Proximal tibial trabecular bone mineral density is related to pain in patients with osteoarthritis. Arthritis Res Ther 19, 200 (2017)
Amini, M. Stiffness of the Proximal Tibial Bone in Normal and Osteoarthritic Conditions: A Parametric Finite Element Simulation Study Master of Science thesis, University of Saskatchewan (2013)
McErlain, D. D. et al. Subchondral cysts create increased intra-osseous stress in early knee OA: A finite element analysis using simulated lesions. Bone 48, 639–646 (2011)
Durr, H. R. et al. The cause of subchondral bone cysts in osteoarthrosis - A finite element analysis. Acta Orthopaedica Scandinavica 75, 554–558 (2004)
Dar, F. H. & Aspden, R. M. A finite element model of an idealized diarthrodial joint to investigate the effects of variation in the mechanical properties of the tissues. Proc Inst Mech Eng H 217, 341–348 (2003)
Nazemi, S. M. et al. Prediction of local proximal tibial subchondral bone structural stiffness using subject-specific finite element modeling: Effect of selected density-modulus relationship. Clin Biomech (Bristol, Avon) 30, 703–712 (2015)
Tuncer, M., Hansen, U. N. & Amis, A. A. Prediction of structural failure of tibial bone models under physiological loads: effect of CT density-modulus relationships. Med Eng Phys 36, 991–997 discussion 991 (2014)
Gray, H. A., Taddei, F., Zavatsky, A. B., Cristofolini, L. & Gill, H. S. Experimental validation of a finite element model of a human cadaveric tibia. J Biomech Eng 130, 031016 (2008)
Mueller, T. L. et al. Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius. Bone 44, 364–371 (2009)
MacNeil, J. A. & Boyd, S. K. Improved reproducibility of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys 30, 792–799 (2008)
Kawalilak, C. E. et al. In vivo precision of three HR-pQCT-derived finite element models of the distal radius and tibia in postmenopausal women. BMC Musculoskelet Disord 17, 389 (2016)
Amini, M. et al. Individual and combined effects of OA-related subchondral bone alterations on proximal tibial surface stiffness: a parametric finite element modeling study. Medical engineering & physics 37, 783–791 (2015)
Goulet, R. W. et al. The relationship between the structural and orthogonal compressive properties of trabecular bone. J Biomech 27, 375–389 (1994)
Frost, H. M. Bone “mass” and the “mechanostat”: a proposal. Anat Rec 219, 1–9 (1987)
Gluer, C. C. et al. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int 5, 262–270 (1995)
Baca, V., Horak, Z., Mikulenka, P. & Dzupa, V. Comparison of an inhomogeneous orthotropic and isotropic material models used for FE analyses. Med Eng Phys 30, 924–930 (2008)
Vijayakumar, V. & Quenneville, C. E. Quantifying the regional variations in the mechanical properties of cancellous bone of the tibia using indentation testing and quantitative computed tomographic imaging. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine 230, 588–593 (2016)
Setton, L. A., Elliott, D. M. & Mow, V. C. Altered mechanics of cartilage with osteoarthritis: human osteoarthritis and an experimental model of joint degeneration. Osteoarthritis Cartilage 7, 2–14 (1999)
Johnston, J. D., McLennan, C. E., Hunter, D. J. & Wilson, D. R. In vivo precision of a depth-specific topographic mapping technique in the CT analysis of osteoarthritic and normal proximal tibial subchondral bone density. Skeletal Radiol 40, 1057–1064 (2011)
Kellgren, J. H. & Lawrence, J. S. Radiological assessment of osteo-arthrosis. Ann Rheum Dis 16, 494–502 (1957)
Kontulainen, S. et al. Analyzing cortical bone cross-sectional geometry by peripheral QCT: comparison with bone histomorphometry. J Clin Densitom 10, 86–92 (2007)
Spoor, C. F., Zonneveld, F. W. & Macho, G. A. Linear measurements of cortical bone and dental enamel by computed tomography: applications and problems. Am J Phys Anthropol 91, 469–484 (1993)
Carey, R. E., Zheng, L., Aiyangar, A. K., Harner, C. D. & Zhang, X. Subject-specific finite element modeling of the tibiofemoral joint based on CT, magnetic resonance imaging and dynamic stereo-radiography data in vivo. J Biomech Eng 136 (2014)
Kazemi, M., Dabiri, Y. & Li, L. P. Recent advances in computational mechanics of the human knee joint. Comput Math Methods Med 2013, 718423 (2013)
Pietruszczak, S., Gdela, K., Webber, C. E. & Inglis, D. On the assessment of brittle–elastic cortical bone fracture in the distal radius. Engineering Fracture Mechanics 74, 1917–1927 (2007)
Johnston, J. D., Masri, B. A. & Wilson, D. R. Computed tomography topographic mapping of subchondral density (CT-TOMASD) in osteoarthritic and normal knees: methodological development and preliminary findings. Osteoarthritis Cartilage 17, 1319–1326 (2009)
Hodges, J. L. & Lehmann, E. L. Estimates of Location Based on Rank-Tests. Ann Math Stat 34, 598-& (1963)
Cohen, J. Statistical power analysis for the behavioral sciences. 2nd edn, (L. Erlbaum Associates, 1988)
Wolf, F. M. & Sage Publications. In Quantitative applications in the social sciences no. 07-059 1 online resource (65 p.) (SAGE, Beverly Hills; London, 1986)
