Reference : Investigation of the Quality of Antibiotics-Based Amoxicillin for Monitoring of Some ...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/226990
Investigation of the Quality of Antibiotics-Based Amoxicillin for Monitoring of Some Different Medicine Markets of Democratic Republic of Congo
English
Kalenda Tshilombo, Nicodème mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (Bologne)]
Ciza Hamuli, Patient mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Mbinze Kindenge, Jérémie mailto [Université de Liège - ULiège > > > chercheur libre médecine]
Habyalimana, Védaste mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Kalenda T. Dibungi [Université de Kinshasa > > > >]
Mavungu Landu, Don Jethro mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Mwamba Tsilumba, Pierrot mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Hubert, Philippe mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Marini Djang'Eing'A, Roland mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
9-Aug-2018
American Journal of Analytical Chemistry
Scientific Research Publishing
9
366- 385
Yes (verified by ORBi)
International
2156-8251
2156-8278
Irvine
CA
[en] Poor Quality Medicines ; Amoxicillin ; LC Method ; Validation ; Survey Study
[en] In order to combat the counterfeiting of drugs, adapted HPLC analytical USP methods were applied to evaluate the quality of the amoxicillin (with or without potassium clavulanate) powder for suspension sold in some Congolese markets. The adaptation has been done by modifying the column dimensions and adjusting the flow rate. According to the intended deployment of these methods in Demo-cratic Republic of Congo (DRC), 3 factors (analyst, day and equipment) were in-volved in the validation step while applying the classic total error measurement approach with an accuracy profile as decision tool. Since adequate results were obtained in terms of selectivity, precision, trueness and accuracy (tolerance limits of life expectancy: -6.0% and 3.8%) for levels of interest concentration, the methods have been considered for routine use on several samples from different provenances and collected in 4 major DRC cities. Out of 278 samples collected, 200 were eligible for analysis from which 28% were found under standards with several figures: pH failure, out of specification for amoxicillin content, absence of potassium clavulanate, physical modifications of the powders. As evidenced by these findings, medicines of low-quality continue to be a major public health problem requiring appropriate action to effectively address this problem.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
Académie de la Recherche et de l'Enseignement Supérieur (ARES-CCD)
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/226990
10.4236/ajac.2018.98029
http://file.scirp.org/Html/2-2201695_86550.htm

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