Paper published in a journal (Scientific congresses and symposiums)
Biochemical parameters related to the metabolic syndrome in healthy dogs and their relationships with body condition score
Gomez Fernandez Blanco, Carlos; Farnir, Frédéric; Höglund, Katja et al.
2016In Journal of Veterinary Internal Medicine
Peer Reviewed verified by ORBi
 

Files


Full Text
2017-Journal_of_Veterinary_Internal_Medicine.pdf
Publisher postprint (984.96 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] The concept of "metabolic syndrome" (MS) gathers all pathophysiological changes that derive from excess body fat in humans. Obese dogs share some components of the MS, such as hypercholesterolemia, hypertriglyceridemia and insulin resistance. However, unlike people, dogs seem to be resistant to obesity-related diseases like atherosclerosis or type-II diabetes mellitus. Elucidating the effects of body composition on lipid metabolism and glucose homeostasis in dogs may allow better understanding of the MS. The aim of this study was to investigate, in healthy dogs, potential associations between body conditions score (BCS) and biochemical parameters involved in the MS. Data from 534 dogs were retrieved as part of the European LUPA project, and included 419 males (15 Boxer, 125 Belgian Shepherd Dog, 35 Cavalier King Charles Spaniel, 40 Dachshund, 39 Doberman, 45 Finnish Lapphund, 66 German Shepherd Dog, and 52 Labrador Retriever) and 115 females (73 Labrador Retriever and 44 Newfoundland). Ages ranged from 2 to 6 years old. Dogs were weighed, a BCS was assigned (using a 1 to 9 scale), and those over 7 or under 2 were excluded. Dogs were considered as healthy based on history, physical examination, CBC, biochemistry, and complete cardiovascular work-up. Circulating concentrations of cholesterol, free fatty acids (FFA), triglycerides, C-reactive protein (CRP), insulin, glucose, fructosamine, cortisol and aldosterone were measured. Spearman's correlations with a Bonferroni-corrected p-value (0,0007) were computed between all variables, both in the overall group and within breeds. A Mann-Whitney test was used to compare dogs categorised into "lean" (BCS < or = 5) and "overweight" (BCS > 5), and ANCOVA was used to test the effect of breed along with the BCS. Taking all dogs into account, BCS was positively correlated with cholesterol, triglycerides and fructosamine, cholesterol with triglycerides and fructosamine, FFA with triglycerides, insulin with CRP and glucose, and fructosamine with cortisol and glucose. Aldosterone was correlated negatively with age and positively with triglycerides and cortisol. Some of these correlations were also observed when testing within breeds. The "overweight" group had significantly higher cholesterol, FFA, triglycerides, fructosamine and aldosterone, and were significantly older than the "lean" group. An effect of BCS persisted on cholesterol, insulin and age despite correction for the different breeds. Metabolic changes occur in association with overweight body condition in otherwise healthy dogs, although breed effects also contribute. Further characterisation of the interactions between body fat deposition and glucose and lipid metabolism may provide insights into canine obesity-related metabolic disturbances
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Gomez Fernandez Blanco, Carlos ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Biochimie médicale
Farnir, Frédéric  ;  Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > Biostatistiques et bioinformatique appliquées aux sc. vétér.
Höglund, Katja
Gouni, Vassiliki
Wiberg, Maria
Lundgren Willesen, Jacob
Hanas, S
Mc Entee, Kathleen ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
Mejer Sorensen, Louise
Tiret, Laurent
Häggström, Jens
Lohi, Hannes
Chetboul, Valérie
Fredholm, Merete
Lequarré, Anne-Sophie ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
German, Alex
Peeters, Dominique ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des animaux de compagnie
Merveille, Anne-Christine  ;  Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux
More authors (8 more) Less
Language :
English
Title :
Biochemical parameters related to the metabolic syndrome in healthy dogs and their relationships with body condition score
Publication date :
2016
Event name :
European college of veterinary internal medicine congress
Event date :
du 8 septembre au 10 septembre
Audience :
International
Journal title :
Journal of Veterinary Internal Medicine
ISSN :
0891-6640
eISSN :
1939-1676
Publisher :
Wiley-Blackwell, United States
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 07 August 2018

Statistics


Number of views
131 (0 by ULiège)
Number of downloads
1 (0 by ULiège)

Bibliography


Similar publications



Contact ORBi