Reference : Biochemical parameters related to the metabolic syndrome in healthy dogs and their re...
Scientific congresses and symposiums : Paper published in a journal
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/226927
Biochemical parameters related to the metabolic syndrome in healthy dogs and their relationships with body condition score
English
Gomez Fernandez Blanco, Carlos mailto [Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Biochimie médicale >]
Farnir, Frédéric mailto [Université de Liège - ULiège > Dpt. de gestion vétérinaire des Ressources Animales (DRA) > Biostatistiques et bioinformatique appliquées aux sc. vétér. >]
Höglund, Katja []
Gouni, Vassiliki []
Wiberg, Maria []
Lundgren Willesen, Jacob []
Hanas, S []
Mc Entee, Kathleen mailto [Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux >]
Mejer Sorensen, Louise []
Tiret, Laurent []
Häggström, Jens []
Lohi, Hannes []
Chetboul, Valérie []
Fredholm, Merete []
Lequarré, Anne-Sophie mailto [Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux >]
German, Alex []
Peeters, Dominique mailto [Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Médecine interne des animaux de compagnie >]
Merveille, Anne-Christine mailto [Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux >]
2016
Journal of Veterinary Internal Medicine
Wiley-Blackwell
Yes (verified by ORBi)
International
0891-6640
1939-1676
United States
European college of veterinary internal medicine congress
du 8 septembre au 10 septembre
[en] The concept of "metabolic syndrome" (MS) gathers all pathophysiological changes that derive from excess body fat in humans. Obese dogs share some components of the MS, such as hypercholesterolemia, hypertriglyceridemia and insulin resistance. However, unlike people, dogs seem to be resistant to obesity-related diseases like atherosclerosis or type-II diabetes mellitus. Elucidating the effects of body composition on lipid metabolism and glucose homeostasis in dogs may allow better understanding of the MS. The aim of this study was to investigate, in healthy dogs, potential associations between body conditions score (BCS) and biochemical parameters involved in the MS.

Data from 534 dogs were retrieved as part of the European LUPA project, and included 419 males (15 Boxer, 125 Belgian Shepherd Dog, 35 Cavalier King Charles Spaniel, 40 Dachshund, 39 Doberman, 45 Finnish Lapphund, 66 German Shepherd Dog, and 52 Labrador Retriever) and 115 females (73 Labrador Retriever and 44 Newfoundland). Ages ranged from 2 to 6 years old. Dogs were weighed, a BCS was assigned (using a 1 to 9 scale), and those over 7 or under 2 were excluded. Dogs were considered as healthy based on history, physical examination, CBC, biochemistry, and complete cardiovascular work-up. Circulating concentrations of cholesterol, free fatty acids (FFA), triglycerides, C-reactive protein (CRP), insulin, glucose, fructosamine, cortisol and aldosterone were measured. Spearman's correlations with a Bonferroni-corrected p-value (0,0007) were computed between all variables, both in the overall group and within breeds. A Mann-Whitney test was used to compare dogs categorised into "lean" (BCS < or = 5) and "overweight" (BCS > 5), and ANCOVA was used to test the effect of breed along with the BCS.

Taking all dogs into account, BCS was positively correlated with cholesterol, triglycerides and fructosamine, cholesterol with triglycerides and fructosamine, FFA with triglycerides, insulin with CRP and glucose, and fructosamine with cortisol and glucose. Aldosterone was correlated negatively with age and positively with triglycerides and cortisol. Some of these correlations were also observed when testing within breeds. The "overweight" group had significantly higher cholesterol, FFA, triglycerides, fructosamine and aldosterone, and were significantly older than the "lean" group. An effect of BCS persisted on cholesterol, insulin and age despite correction for the different breeds.

Metabolic changes occur in association with overweight body condition in otherwise healthy dogs, although breed effects also contribute. Further characterisation of the interactions between body fat deposition and glucose and lipid metabolism may provide insights into canine obesity-related metabolic disturbances
http://hdl.handle.net/2268/226927

File(s) associated to this reference

Fulltext file(s):

FileCommentaryVersionSizeAccess
Restricted access
2017-Journal_of_Veterinary_Internal_Medicine.pdfPublisher postprint961.88 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.