Reference : Comparing the qualitative performances of handheld NIR and Raman spectrometers for th...
Scientific congresses and symposiums : Poster
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/226676
Comparing the qualitative performances of handheld NIR and Raman spectrometers for the analysis of falsified pharmaceutical products.
English
[fr] Comparaison des performances qualitatives des spectromètres PIR et Raman portables pour l'analyse de produits pharmaceutiques falsifiés.
Ciza Hamuli, Patient mailto [Université de Liège - ULiège > > > Doct. sc. bioméd. & pharma. (paysage)]
Waffo Tchounga, Christelle Ange mailto [Université de Liège - ULiège > > > stage conv. étrangères ou CFB en médecine]
Coic, Laureen mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Mbinze Kindenge, Jérémie mailto [Université de Kinshasa > pharmacie galénique et analyse des médicament > analyse des médicaments > >]
Ngono, Rose mailto [University of YaoundéI > Faculty of Medicine and Biomedical Sciences and National Drug > Control and Valuation (LANACOME) > >]
Marini Djang'Eing'A, Roland mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Hubert, Philippe mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Sacre, Pierre-Yves mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Ziemons, Eric mailto [Université de Liège - ULiège > Département de pharmacie > Département de pharmacie >]
Sep-2018
2x1m
Yes
No
International
11th International Symposium on Drug Analysis and the 29th International Symposium on Pharmaceutical and Biomedical Analysis.
du 09 Septembre au 12 Septembre 2018
the International Symposium DA-PBA 2018
Louvain
Belgique
[en] NIR spectroscopy ; Raman spectroscopy ; Clustering algorithm ; DD-SIMCA ; PLS-DA
[en] The last decade has seen a significant growth of the pharmaceutical market of emerging countries to the point that it has induced many falsifications. Research activities have followed this growth but not proportionately. Recently, several chemical analysis methods for the detection of counterfeit or falsified drugs have been developed using spectroscopic techniques.
In this study, different spectrometers were used to collect near-infrared (NIR) and Raman spectral data sets of selected drugs to help improve existing methods. The objective of this work was to evaluate the qualitative performances of the NIR and Raman spectrometers; two benchtop equipment (NIR and Raman) and four handheld ones (three Raman and one NIR) were used. In particular, we made a critical comparison in the evaluation of the accuracy of the prediction.
The predictive ability of the different equipments was compared statistically using chemometrics: clustering algorithm, soft modeling (DD-SIMCA) and hard modeling (PLS-DA).
All these chemometric strategies were applied on each equipment. Clustering approaches, DD-SIMCA and PLSDA enabled us to compare the qualitative performances of handheld NIR and Raman equipment and to make a critical analysis of their use in the field of the detection of falsified drugs.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
ARES-PFS ; Service public de Wallonie : Direction générale opérationnelle de l'économie, de l'emploi et de la recherche - DG06
création d'un centre d'excellence en Assurance et Contrôle de Qualité des médicaments et produits de santé
Researchers ; Professionals ; General public
http://hdl.handle.net/2268/226676

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