Reference : Hen egg white lysozyme is less active against Gardnerella vaginalis biofilm than huma...
Scientific journals : Article
Life sciences : Multidisciplinary, general & others
Life sciences : Microbiology
http://hdl.handle.net/2268/226584
Hen egg white lysozyme is less active against Gardnerella vaginalis biofilm than human lysozyme
English
Thellin, Olivier mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie >]
Zorzi, Danièle mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
MELIN, Pierrette mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de microbiologie clinique >]
DELVENNE, Philippe mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service d'anatomie et cytologie pathologiques >]
Heinen, Ernst mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Zorzi, Willy mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie >]
Elmoualij, Benaïssa mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Histologie >]
QUATRESOOZ, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service dermatopathologie >]
Feb-2018
Microbiology Research International
6
1
1-6
Yes
International
2354-2128
[en] Hen egg white lysozyme ; recombinant human lysozyme ; Gardnerella vaginalis ; bofilm
[en] Bacterial vaginosis is a condition that affects millions of women worldwide. In most cases, it can be linked to the presence of Gardnerella vaginalis. Classical metronidazole treatments can lead to recurrence of bacterial vaginosis in more than 50% of cases due to its inability to fully eradicate the infection. This can be due to protective shielding of G. vaginalis by the biofilm it synthesizes. We showed previously that the co- administration of recombinant human lysozyme, as a biofilm-degrading agent, with the antibiotic greatly improves its efficiency in vitro. Lysozyme purified from egg white is less expensive than recombinant human lysozyme and is commonly produced as an additive for human consumption. Our goal was to compare the effects of recombinant human lysozyme with that of egg white lysozyme alongside a conventional antibiotic treatment for bacterial vaginosis, using in vitro vaginal biofilm models. The results obtained here show that recombinant human lysozyme is a more efficient biofilm-degrading agent than egg white lysozyme and therefore constitutes a better choice as an anti-biofilm co-treatment for current vaginal antibiotherapy against G. vaginalis infection.
Région Wallonne (Belgium), contract RW 816770
Researchers ; Professionals
http://hdl.handle.net/2268/226584

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