Oxytocin; Pain; Analgesia; Placebo; Central nervous system
Abstract :
[en] Pain is an essential subjective warning symptom that can transform into a disease when it becomes chronic and affects the patients’ quality of life. The oxytocinergic system has long been known to play a physiological role in pain perception and its psychological aspects. Despite potential implications for pain treatment, the oxytocinergic system has not yet been therapeutically targeted in clinical practice. This narrative review explores the latest scientific findings on the subject, and discusses some of the unexplored leads for the clinical use of oxytocin in the domain of pain treatment.
Loeser J. D., Treede R. D., The Kyoto protocol of IASP basic pain terminology, PAIN, 137; 473-77, 2008.
Szukiewicz D., Bilska, A., Mittal T. K., Stangret A., Wejman, J., Szewczyk G., Pylzak M., Zamlynski J., Myometrial contractility influences oxytocin receptor (OXTR) expression in term trophoblast cells obtained from the maternal surface of the human placenta, BMC PREGNANCY AND CHILDBIRTH, 15, 1220, 2015.
Demirel G., Guler H., The Effect of Uterine and Nipple Stimulation on Induction With Oxytocin and the Labor Process, WORLDVIEWS EVID BASED NURS., 12 (5), 273-80, 2005.
Basbaum A. I., Jessel, T. M., The perception of pain, PRINCIPLES OF NEUROSCIENCE, 4TH ED., 472-491, New York, McGraw-Hill, 2000.
Purves D., Augustine G. J., Fitzpatrick W. C, Hall W. C, LaMantia A.-S., McNamara J.O., White, L. E., The Somatic Sensory System, NEUROSCIENCE, 4TH ED., 207-30, Sunderland, Sinauer Associates, 2008.
Almeida T. F., Roizenblatt S., Tufik S., Afferent pain pathways: a neuroanatomical review, Brain Res., 1000 (1-2), 40-56, 2004.
Tracy L. M., Georgiou-Karistianis N., and Gibson., S. J., Giummarra M. J., Oxytocin and the modulation of pain experience: Implications for chronic pain management, NEUROSCI BIOBEHAV REV., 0, 54-67, 2015.
Martin J. H., Somatic Sensation: Spinal Systems for Pain, Temperature, and Itch, NEUROANATOMY: TEXT AND ATLAS, 4TH ED., 107-26, New York, McGraw-Hill, 2012.
Reddi D., Curran N., Stephens R., An introduction to pain pathways and mechanisms, BR J HOSP MED., 74 (Suppl 12), 188-91, 2013.
Heinricher M. M., Tavares I., Leith J. L., Lumb B. M., Descending control of nociception: specificity, recruitment and plasticity, BRAIN RES REV., 60 (1), 214-25, 2009.
Know M., Altin M., Duenas H., Alev L., The role of descending inhibitory pathways on chronic pain modulation and clinical implications, PAIN PRACTICE, 14 (7), 656-67, 2014.
Eliava M., Melchior M., Knobloch-Bollmann H. K., Wahis J., da Silva Gouveia M., Tang Y., Ciobanu A. C, Triana del Rio R., Roth L. C, Althammer F., Chavant V., Goumon Y., Gruber T., Petit-Demouliere N., Busnelli M., Chini B., Tan L. L., Mitre M., Froemke R. C, Chao M. V., Giese G., Sprengel R., Kuner R., Poisbeau P., Seeburg P. H., Stoop R., Charlet A., Grinevich V., A New Population of Parvocellular Oxytocin Neurons Controlling Magnocellular Neuron Activity and Inflammatory Pain Processing, NEURON, 89 (6), 1291-1304, 2016.
Gimpl G., Fahrenholz F., The Oxytocin Receptor System: Structure, Function, and Regulation, PHYSIOL REV., 81 (2), 629-83, 2001.
Kim S. H., MacIntyre D. A., Hanyaloglu A. C, Blanks A. M., Thornton S., Bennett S. R., Terzidou V., The oxytocin receptor antagonist, Atosiban, activates pro-inflammatory pathways in human amnion via G(αi) signalling, MOL CELL ENDOCRINOL, 420, 11-23, 2016.
Terzidou V., Blanks A. M., Kim S. H., Thornton S., Bernett P. R., Labor and Inflammation Increase the Expression of Oxytocin Receptor in Human Amnion, BIOL REPROD., 84 (3), 546-552, 2011.
Chen D., Zhao J., Wang H., An N., Zhou Y., Fan J., Luo J., Su W., Liu C, Li J., Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury. Sci REP, 5, 11731, 2015.
Jankowski M., Bissonauth V., Gao L., Gangal M., Wang D., Danalache B., Wang Y., Stoyanova E., Cloutier G., Blaise, G., Anti-inflammatory effect of oxytocin in rat myocardial infarction, BASIC RES CARDIOL, 105 (2), 205-18, 2010.
Barman S., Barrett K., Boitano S., Brooks H., Hypothalamic Regulation of Hormonal Functions, GANONG'S REVIEW OF MEDICAL PHYSIOLOGY, 23RD ED., 289-300, New York, McGraw Hill, 2009.
Crowley W. R., Neuroendocrine Regulation of Lactation and Milk Production, COMPR PHYSIOL, 5 (1), 225-91, 2015.
Rash J. A., Aguirre-Camacho A., and Campbell., T. S., Oxytocin and Pain: A Systematic Review and Synthesis of Findings, CLIN J PAIN, 30 (5), 453-62, 2014.
Benarroch E. E., Pain-autonomic interactions, NEUROL SCI, 27 (Suppl 2), 130-3, 2006.
Meyer-Lindenberg A., Domes G., Kirsch P., Heinrichs M., Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine, NAT REV NEUROSCI, 12 (9), 524-38, 2011.
Keefe F. J., Lumley M., Anderson T., Lynch T., Carson K. L., Pain and emotion: New research directions, J CLIN PSYCHOL, 57 (4), 587-607, 2001.
Crock L. W., Kolber B. J., Morgan C. D., Sadler K. E., Vogt S. K., Bruchas M. R., Gereau R.W., Central Amygdala Metabotropic Glutamate Receptor 5 in the Modulation of Visceral Pain, J NEUROSCI, 32 (41), 14217-26, 2012.
De Bonis M., Torricelli M., Leoni L., Berti P., Ciani V., Puzzutiello R., Severi F. M., Petraglia F., Carbetocin versus oxytocin after caesarean section: similar efficacy but reduced pain perception in women with high risk of postpartum haemorrhage, J MATERN FETAL NEONATAL MED., 25 (6), 732-5, Jun 2012.
Futagamia H., Sakumab Y., Kondo Y., Oxytocin mediates copulation-induced hypoalgesia of male rats, NEUROSCI LETT, 618, 122-6, 2016.
Paloyelis Y, Krah C, Maltezos S., Williams S. C, Howard M. A., Fotopoulou A., The Analgesic Effect of Oxytocin in Humans: A Double-Blind, Placebo-Controlled Cross-Over Study Using Laser-Evoked Potentials, J NEUROENDOCRINOL, 28 (4), 2016.
Rash J. A., Campbell T. S., The Effect of Intranasal Oxytocin Administration on Acute Cold Pressor Pain: A Placebo-Controlled, Double-Blind, Within-Participants Crossover Investigation, PSYCHOSOM MED., 76 (6), 422-9, Jul-Aug 2014.
Zunhammer M., Geis S., Busch V., Greenlee M. W., Eichhammer P., Effects of Intranasal Oxytocin on Thermal Pain in Healthy Men: A Randomized Functional Magnetic Resonance Imaging Study, PSYCHOSOM MED., 77 (2), 156-66, Feb-Mar 2015.
Zunhammer M., Geis S., Busch V., Eichhammer P., Greenlee M. W., Pain modulation by intranasal oxytocin and emotional picture viewing - a randomized double-blind fMRI study, Sci REP, 6, 31606, 2016.
Colloca L., Klinger R., Flor H., Bingel U., Placebo analgesia: Psychological and neurobiological mechanisms, PAIN, 154 (4), 511-14, 2013.
Zubieta J.-K., Stohler C. S., Neurobiological Mechanisms of Placebo Responses, ANN N YACAD SCI., 1156, 198-210, 2009.
Kessner S., Sprenger C, Wrobel N., Wiech K., Bingel U., Effect of Oxytocin on Placebo Analgesia: A Randomized Study, JAMA, 310 (16), 1733-735, 2013.
Yi X., Manickam D. S., Brynskikh A., and Kabanov., A. V., Agile Delivery of Protein Therapeutics to CNS, J CONTROL RELEASE, 28, 637-63, 2014.
Colloca L., Klinger R., Flor H., Bingel U., Placebo analgesia: Psychological and neurobiological mechanisms, PAIN, 154 (4), 511-14, 2013.