Reference : Norovirus recombinants: recurrent in the field, recalcitrant in the lab – a scoping r...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/226040
Norovirus recombinants: recurrent in the field, recalcitrant in the lab – a scoping review of recombination and recombinant types of noroviruses
English
Ludwig, Louisa mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Virologie vétérinaire et maladies virales animales >]
Mauoy, Axel [Federal Agency for the Safety of the Food Chain > Staff direction for risk assessment, Control Policy > > >]
Thiry, Etienne mailto [Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Virologie vétérinaire et maladies virales animales >]
2018
Journal of General Virology
Society for General Microbiology
Yes (verified by ORBi)
International
0022-1317
1465-2099
United Kingdom
[en] Norovirus ; Recombination ; Evolution
[en] Noroviruses are recognized as the major global cause of sporadic and epidemic non-bacterial gastroenteritis in humans. Molecular mechanisms driving norovirus evolution are the accumulation of point mutations and recombination. Intragenotypic recombination has long been postulated to be a driving force of GII.4 noroviruses, the predominant genotype circulating in humans for over two decades. Increasingly, emergence and re-emergence of different intragenotype recombinants have been reported. The number and types of norovirus recombinants remained undefined until the 2007 JGenVirol research article ‘Norovirus recombination’ reported an assembly of 20 hitherto unclassified intergenotypic norovirus recombinant types. In the intervening decade, a host of novel recombinants has been analysed. New recombination breakpoints have been described, in vitro and in vivo studies supplement in silico analyses, and advances have been made in analysing factors driving norovirus recombination. This work presents a timely overview of these data and focuses on important aspects of norovirus recombination and its role in norovirus molecular evolution. An overview of intergenogroup, intergenotype, intragenotype and ‘obligatory’ norovirus recombinants as detected via in silico methods in the field is provided, enlarging the scope of intergenotypic recombinant types to 80 in total, and notably including three intergenogroup recombinants. A recap of advances made studying norovirus recombination in the laboratory is given. Putative drivers and constraints of norovirus recombination are discussed and the potential link between recombination and norovirus zoonosis risk is examined.
Fonds Léon Fredericq ; German Academic Exchange Service ; Service public fédéral Service Santé Publique, Séecurité de la Chaîne alimentaire et Environnement
http://hdl.handle.net/2268/226040
10.1099/jgv.0.001103

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