Article (Scientific journals)
Separation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes.
Fillet, Marianne; Bechet, Isabelle; Piette, Véronique et al.
1999In Electrophoresis, 20 (9), p. 1907-15
Peer Reviewed verified by ORBi
 

Files


Full Text
AINSNACEElectrophoresis1999.pdf
Publisher postprint (218.67 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Anti-Inflammatory Agents, Non-Steroidal/isolation & purification; Buffers; Electrolytes; Electrophoresis, Capillary/methods; Hydrogen-Ion Concentration; Solvents; Temperature
Abstract :
[en] The aim of the present work was to investigate the separation of nonsteroidal anti-inflammatory drugs (NSAIDs: niflumic acid, flufenamic acid, piroxicam, alclofenac, tiaprofenic acid, flurbiprofen, suprofen, ketoprofen, naproxen, indomethacin, carprofen, indoprofen, sulindac) in capillary electrophoresis (CE) using completely nonaqueous systems. The influence of different parameters such as nature and proportion of organic solvent (methanol, acetonitrile, 2-propanol), apparent pH (ranging from 7 to 9) and temperature (ranging from 25 to 40 degrees C) on selectivity and migration times were studied systematically in an uncoated fused-silica capillary. A nonaqueous electrolyte made of 50 mM ammonium acetate - 13.75 mM ammonia in methanol proved to resolve 11 NSAIDs at 25 degrees C and 13 NSAIDs at 36 degrees C, both within 13 min and without a modifier besides the methanol itself. The same buffer containing 30% acetonitrile provides a satisfactory separation for 13 NSAIDs within 14 min at 25 degrees C.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Bechet, Isabelle;  Université de Liège - ULiège > Analyse des Médicaments
Piette, Véronique;  Université de Liège - ULiège > Analyse des médicaments
Crommen, Jacques ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Separation of nonsteroidal anti-inflammatory drugs by capillary electrophoresis using nonaqueous electrolytes.
Publication date :
1999
Journal title :
Electrophoresis
ISSN :
0173-0835
eISSN :
1522-2683
Publisher :
Vch Publishers, Weinheim, Germany
Volume :
20
Issue :
9
Pages :
1907-15
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 17 September 2009

Statistics


Number of views
279 (5 by ULiège)
Number of downloads
863 (4 by ULiège)

Scopus citations®
 
55
Scopus citations®
without self-citations
55
OpenCitations
 
43

Bibliography


Similar publications



Contact ORBi