Designed combination of chiral selectors for adjustment of enantioseparation selectivity in capillary electrophoresis.

[en] In this study an attempt has been made to explain the reasons for changing the enantioseparation selectivity in some dual cyclodextrin (CD) systems compared to the use of single chiral selectors in capillary electrophoresis (CE). An explanation for selectivity changes is proposed based on the effect of the chiral selector on the mobility of the analyte. In order to support the proposed mechanism, several dual systems were designed on the basis of the known recognition pattern of enantiomers for individual CDs. In most cases the separation selectivity could be adjusted in a designed way. There was no experimental evidence for simultaneous binding of a given chiral analyte with both chiral selectors or of chiral recognition of an analyte complex with one CD by another CD.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Chankvetadze, Bezhan; University of Munster, Germany

Crommen, Jacques ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments

Blaschke, G.; University of Munster, Germany

Language :

English

Title :

Designed combination of chiral selectors for adjustment of enantioseparation selectivity in capillary electrophoresis.

Publication date :

1999

Journal title :

Electrophoresis

ISSN :

0173-0835

eISSN :

1522-2683

Publisher :

Vch Publishers, Weinheim, Germany

Volume :

Issue :

Pages :

2691-7

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 17 September 2009

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