Article (Scientific journals)
Warning about the Use of Critical-Size Defects for the Translational Study of Bone Repair: Analysis of a Sheep Tibial Model
Lammens, J.; Maréchal, Marina; Geris, Liesbet et al.
2017In Tissue Engineering. Part C, Methods, 23 (11), p. 694-699
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Keywords :
Animals; Bone; Physiological models; Repair; Tissue; Tissue engineering; Animal model; Autologous grafts; Bone repair; Critical size defect; Human bodies; Large defects; Medicinal products; Surgical procedures; Defects; Article
Abstract :
[en] The repair of large long bone defects requires complex surgical procedures as the bone loss cannot simply be replaced by autologous grafts due to an insufficient bone stock of the human body. Tissue engineering strategies and the use of Advanced Therapy Medicinal Products (ATMPs) for these reconstructions remain a considerable challenge, in particular since robust outcomes in well-defined large animal models are lacking. To be suitable as a model for treatment of human sized bone defects, we developed a large animal model in both skeletally immature and mature sheep and made close observations on the spontaneous healing of defects. We warn for the spontaneous repair of large defects in immature animals, which can mask the (in)effectiveness of ATMP therapies, and propose the use of large 4.5 cm defects that are pretreated with a polymethylmethacrylate (PMMA) spacer in skeletally mature animals. © Copyright 2017, Mary Ann Liebert, Inc. 2017.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Lammens, J.;  Department of Orthopaedic Surgery, University Hospitals, KU Leuven, Leuven, Belgium, Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium, Department of Orthopaedic Surgery, University Hospitals, KU Leuven, Weligerveld 1, Pellenberg, Belgium
Maréchal, Marina
Geris, Liesbet  ;  Université de Liège - ULiège > Département d'aérospatiale et mécanique > Génie biomécanique
Van Der Aa, J.;  Faculty of Medicine, KU Leuven, Leuven, Belgium
Van Hauwermeiren, H.;  Medanex Clinic, Facility for Preclinical CRO, Diest, Belgium
Luyten, F. P.;  Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
Delport, H.;  Department of Orthopaedic Surgery, University Hospitals, KU Leuven, Leuven, Belgium, Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, Leuven, Belgium
Language :
English
Title :
Warning about the Use of Critical-Size Defects for the Translational Study of Bone Repair: Analysis of a Sheep Tibial Model
Publication date :
2017
Journal title :
Tissue Engineering. Part C, Methods
ISSN :
1937-3384
eISSN :
1937-3392
Publisher :
Mary Ann Liebert Inc.
Volume :
23
Issue :
11
Pages :
694-699
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 June 2018

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