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Cardiac Monitoring During Clinical Trials
MOONEN, Marie; Frere, Pol; Lancellotti, Patrizio et al.
2016In Anticancer Treatments and Cardiotoxicity 1st Edition Mechanisms, Diagnostic and Therapeutic Interventions
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Keywords :
Adjuvant setting; Cardiac monitoring; Cardiac toxicity; Clinical trials; Heart failure; Trastuzumab
Abstract :
[en] The prognosis of breast cancer has greatly improved over time, particularly through the development of targeted therapy. Close cardiac monitoring during clinical trials investigating anticancer therapeutics is a field in cardiology that emerged 15 years ago. Indeed, anticancer agent-related cardiac dysfunction has been a nonanticipated adverse event in a phase 3 trial testing trastuzumab for metastatic breast cancer that overexpresses HER2. We propose hereby a description of the different strategies worked out to prevent cardiac dysfunction attributable to trastuzumab when it was evaluated in the adjuvant setting. This approach is still the fact of the studies designed since that and now, as a panel of cardiac toxicity has been associated with the development of these targeted therapies. © 2017 Elsevier Inc. All rights reserved.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
MOONEN, Marie ;  Centre Hospitalier Universitaire de Liège - CHU > Service de cardiologie
Frere, Pol ;  Université de Liège - ULiège > Interface Entreprises-Université
Lancellotti, Patrizio  ;  Université de Liège - ULiège > Département des sciences cliniques > Imagerie cardiaque fonctionnelle par échographie
Jerusalem, Guy  ;  Université de Liège - ULiège > Département des sciences cliniques > Oncologie
Language :
English
Title :
Cardiac Monitoring During Clinical Trials
Publication date :
2016
Main work title :
Anticancer Treatments and Cardiotoxicity 1st Edition Mechanisms, Diagnostic and Therapeutic Interventions
Publisher :
Elsevier Inc.
Pages :
387-399
Peer reviewed :
Peer reviewed
Commentary :
9780128025093
Available on ORBi :
since 14 June 2018

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