Variations of circulating cardiac biomarkers during and after anthracycline-containing chemotherapy in breast cancer patients

[en] Background: Over time, the chance of cure after the diagnosis of breast cancer has been increasing, as a consequence of earlier diagnosis, improved diagnostic procedures and more effective treatment options. However, oncologists are concerned by the risk of long term treatment side effects, including congestive heart failure (CHF). Methods: In this study, we evaluated innovative circulating cardiac biomarkers during and after anthracycline-based neoadjuvant chemotherapy (NAC) in breast cancer patients. Levels of cardiac-specific troponins T (cTnT), N-terminal natriuretic peptides (NT-proBNP), soluble ST2 (sST2) and 10 circulating microRNAs (miRNAs) were measured. Results: Under chemotherapy, we observed an elevation of cTnT and NT-proBNP levels, but also the upregulation of sST2 and of 4 CHF-related miRNAs (miR-126-3p, miR-199a-3p, miR-423-5p, miR-34a-5p). The elevations of cTnT, NT-proBNP, sST2 and CHF-related miRNAs were poorly correlated, suggesting that these molecules could provide different information. Conclusions: Circulating miRNA and sST2 are potential biomarkers of the chemotherapy-related cardiac dysfunction (CRCD). Nevertheless, further studies and long-term follow-up are needed in order to evaluate if these new markers may help to predict CRCD and to identify the patients at risk to later develop CHF. © 2018 The Author(s).

Disciplines :

Cardiovascular & respiratory systems

Author, co-author :

Freres, Pierre ; Université de Liège - ULiège > Département des sciences cliniques > Oncologie

Bouznad, N.; Heart Valve Clinic, University Hospital (CHU) and University of Liège, GIGA Cardiovascular Sciences, Department of Cardiology, Liège, Belgium

Servais, Laurence ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences

JOSSE, Claire ; Centre Hospitalier Universitaire de Liège - CHU > Service d'oncologie médicale

Wenric, Stéphane ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine

Poncin, Aurélie ; Université de Liège - ULiège > Département des sciences cliniques > Oncologie

Thiry, Jean ; Université de Liège - ULiège > Département de sciences dentaires > Prothèse dentaire fixe - Anatomie bucco-dentaire

Moonen, M.; Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy

Oury, Cécile ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences

Lancellotti, Patrizio ; Université de Liège - ULiège > Département des sciences cliniques > Cardiologie - Pathologie spéciale et réhabilitation

Bours, Vincent ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine

Jerusalem, Guy ; Université de Liège - ULiège > Département des sciences cliniques > Oncologie

Language :

French

Title :

Variations of circulating cardiac biomarkers during and after anthracycline-containing chemotherapy in breast cancer patients

Publication date :

2018

Journal title :

BMC Cancer

eISSN :

1471-2407

Publisher :

BioMed Central

Volume :

Issue :

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

PMID:29378531

Available on ORBi :

since 14 June 2018

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