Atypical myopathy in Père David’s deer (Elaphurus davidianus) associated with ingestion of hypoglycin A

myopathy; atypical myopathy; Elaphurus davidianus; hypoglycin A; MCPA-carnitine; milu; sycamore maple; acer pseudoplatanus; myopathie; myopathie atypique; hypoglycine A; érable

Abstract :

[en] From 2004 until 2016, 21 Père David’s deer (Elaphurus davidianus) have died for unknown reason at Zoo Duisburg. Hypoglycin A and MCPA-carnitine were found in the blood of Père David’s deer and thus, hypoglycin A intoxication was considered to be a poten-tial cause for the myopathies by ingestion of sycamore maple samaras that were present in the enclosure of the affected animals.

Research Center/Unit :

FARAH - Fundamental and Applied Research for Animals and Health - ULiège

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Bunert, C.

Langer, S.

Votion, Dominique ; Université de Liège - ULiège > Scientifiques attachés au Doyen (F MV)

BOEMER, François ; Centre Hospitalier Universitaire de Liège - CHU > Service de génétique

Müller, A.

Ternes, K.

Liesegang, A.

Language :

English

Title :

Atypical myopathy in Père David’s deer (Elaphurus davidianus) associated with ingestion of hypoglycin A

Alternative titles :

[en] Myopathie atypique chez le cerf du père David (Elaphurus davidianus) associée à l'ingestion d'hypoglycine A

Publication date :

12 May 2018

Journal title :

Journal of Animal Science

ISSN :

0021-8812

eISSN :

1525-3163

Publisher :

American Society of Animal Science, United States

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://academic.oup.com/jas/advance-article-abstract/doi/10.1093/jas/sky200/4995522

Commentary :

De 2004 à 2016, 21 cerfs du Père David (Elaphurus davidianus) sont morts pour une raison inconnue au Zoo de Duisburg. L'hypoglycine A et la MCPA-carnitine ont été retrouvées dans le sang du cerf du Père David et l'intoxication à l'hypoglycine A a été considérée comme une cause potentielle de myopathies par ingestion de samares d'érables sycomores présents dans l'enclos des animaux atteints.

Available on ORBi :

since 12 June 2018

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Bibliography

Al-Dissi, A. N., B. R. Blakley, and M. R. Woodbury. 2011. Selenium toxicosis in a white-tailed deer herd. Can. Vet. J. 52:70-73
Baise, E., J. A. Habyarimana, H. Amory, F. Boemer, C. Douny, P. Gustin, C. Marcillaud-Pitel, F. Patarin, M. Weber, and D. M. Votion. 2016. Samaras and seedlings of Acer pseudoplatanus are potential sources of hypoglycin A intoxication in atypical myopathy without necessarily inducing clinical signs. Equine Vet. J. 48:414-417. doi:10.1111/evj.12499
Bannikow, A. G., B. Grzimek, L. Heck, D. Heinemann, W. G. Heptner, H. G. Klös, E. M. Lang, E. Thenius, and F. Walther. 2000. Grzimeks tierleben. Säugetiere 4. [Animal life encyclopedia. Mammals 4]. Vol. 13. Weltbild Verlag, Augsburg, Germany
Barceloux, D. G. 2009. Akee fruit and Jamaican vomiting sickness (Blighia sapida Köenig). Dis Mon. 55(6):318-326. doi:10.1016/j.disamonth.2009.03.002
Blake, O. A., M. R. Bennink, and J. C. Jackson. 2006. Ackee (Blighia sapida) hypoglycin A toxicity: dose response assessment in laboratory rats. Food Chem. Toxicol. 44:207-213. doi:10.1016/j.fct.2005.07.002
Bochnia, M., J. Ziegler, J. Sander, A. Uhlig, S. Schaefer, S. Vollstedt, M. Glatter, S. Abel, S. Recknagel, G. F. Schusser, et al. 2015. Hypoglycin A content in blood and urine discriminates horses with atypical myopathy from clinically normal horses grazing on the same pasture. Plos One 10:e0136785. doi:10.1371/journal.pone.0136785
Boemer, F., M. Deberg, R. Schoos, E. Baise, H. Amory, G. Gault, J. Carlier, Y. Gaillard, C. Marcillaud-Pitel, and D. Votion. 2015. Quantification of hypoglycin A in serum using aTRAQ(®) assay. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 997:75-80. doi:10.1016/j. jchromb.2015.06.004
Boemer, F., J. Detilleux, C. Cello, H. Amory, C. Marcillaud-Pitel, E. Richard, G. van Galen, G. van Loon, L. Lefère, and D. M. Votion. 2017. Acylcarnitines profile best predicts survival in horses with atypical myopathy. Plos One 12:e0182761. doi:10.1371/journal.pone.0182761
Cassart, D., E. Baise, Y. Cherel, C. Delguste, N. Antoine, D. Votion, H. Amory, F. Rollin, A. Linden, F. Coignoul, et al. 2007. Morphological alterations in oxidative muscles and mitochondrial structure associated with equine atypical myopathy. Equine Vet. J. 39:26-32. doi:10.2746/0425. 16407X157765
Chace, D. H., R. Pons, C. A. Chiriboga, D. J. McMahon, I. Tein, E. W. Naylor, and D. C. De Vivo. 2003. Neonatal blood carnitine concentrations: normative data by electrospray tandem mass spectometry. Pediatr. Res. 53:823-829. doi:10.1203/01.PDR.0000059220.39578.3D
von Engelhardt, W. 2010. Physiologie der haustiere. [Physiology of domesticated animals]. 3rd ed. Enke, Stuttgart, Germany. p. 394
Forth, W., D. Henschler, W. Rummel, U. Förstermann, and K. Starke. 2001. Allgemeine und spezielle pharmakologie und toxikologie. [General and specific pharmacology and toxicology]. 8th ed. Urban & Fischer, Munich, Germany. p. 1054-1055
Gaisler, J., and J. Zejda. 1997. Enzyklopädie der säugetiere. [Encyclopedia of mammals]. Dausien, Hanau, Germany. p. 414
van Galen, G., C. Marcillaud Pitel, C. Saegerman, F. Patarin, H. Amory, J. D. Baily, D. Cassart, V. Gerber, C. Hahn, P. Harris, et al. 2012. European outbreaks of atypical myopathy in grazing equids (2006-2009): spatiotemporal distribution, history and clinical features. Equine Vet. J. 44:614-620. doi:10.1111/j.2042-3306.2012.00556.x
Grzimek, B. 1988. Grzimeks Enzyklopädie. Säugetiere. Band 5 [Grzimeks Encylopedia. Mammals]. Vol. 5. Kindler, München, Germany. p. 161-164
Habyarimana, J. A., E. Baise, C. Douny, M. Weber, F. Boemer, P. De Tullio, T. Franck, C. Marcillaud-Pitel, M. Federich, A. Mouithys-Mickalad, et al. 2017. Development of an HPTLC method for determination of hypoglycin A in aqueous extracts of seedlings and samaras of Acer species. bioRxiv :148262. doi:10.1101/148262
Ikeda, Y., and K. Tanaka. 1990. Selective inactivation of various acyl-CoA dehydrogenases by (methylenecyclopropyl) acetyl-CoA. Biochim. Biophys. Acta. 1038:216-221. doi:10.1016/0167-4838(90)90208-W
Kern, C. 2008. Beobachtungen zur Fortpflanzungsbiologie beim Davidshirsch (Elaphurus davidianus Milne Edwards, 1866) im Tierpark Berlin [Observations about the biology of reproduction in Père David's deer (Elaphurus davidianus Milne Edwards, 1866) at Tierpark Berlin]. In: Tierpark Berlin, editor. Milu. Book 4, Vol. 12. Berlin, Germany. p. 319
McGavin, M. D., and J. F. Zachary. 2009. Pathologie der haustiere. [Pathology of domestic animals]. 1st ed. Elsevier, München, Germany. p. 898
McKenzie, R. K., F. I. Hill, J. A. Habyarimana, F. Boemer, and D. M. Votion. 2016. Detection of hypoglycin A in the seeds of sycamore (Acer pseudoplatanus) and box elder (A. Negundo) in New Zealand; the toxin associated with cases of equine atypical myopathy. N. Z. Vet. J. 64:182-187. doi :10.1080/00480169.2015.1123123
Moritz, A. 2013. Klinische labordiagnostik in der tiermedizin. [Clinical laboratory diagnostics in veterinary medicine]. 7th ed. Schattauer, Stuttgart, Germany. p. 254, 320-322
Osmundsen, H., and H. S. Sherratt. 1975. A novel mechanism for inhibition of beta-oxidation by methylenecyclopropylacetyl-CoA, a metabolite of hypoglycin. FEBS Lett. 55:38-41. doi:10.1016/0014-5793(75)80951-3
Schürer, U., and A. Stadler. 2016. Pater Davids Hirsch oder Milu (Elaphurus davidianus Milne Edwards, 1866), 150
Jahre, 1865 bis 2015 [Père David's Deer or Milu (Elaphurus davidianus Milne Edwards, 1866), 150 years, 1865-2015]. In: Kühne, R., editor. Der Zoologische Garten. Issue 6. 2016. [The Zoological Garden. Issue 6. 2016]. Vol. 85. Elsevier, Berlin, Germany. p. 389-396
Valberg, S. J., B. T. Sponseller, A. D. Hegemann, J. Earing, J. B. Bender, K. L. Martinson, S. E. Patterson, L. Sweetman. 2013. Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion od hypoglycin A within seeds of the box elder tree. Equine Vet. J. 45(4):419-426. doi:10.1111/j.2042-3306.2012.00684.x
Votion, D. M. 2016. Atypical myopathy: an update. In Practice 38:241-246. doi:10.1136/inp.i1859
Votion, D. M., G. van Galen, L. Sweetman, F. Boemer, P. de Tullio, C. Dopagne, L. Lefère, A. Mouithys-Mickalad, F. Patarin, S. Rouxhet, et al. 2014. Identification of methylenecyclopropyl acetic acid in serum of European horses with atypical myopathy. Equine Vet. J. 46:146-149. doi:10.1111/evj.12117
Votion, D. M., A. Linden, C. Delguste, H. Amory, E. Thiry, P. Engels, G. van Galen, R. Navet, F. Sluse, D. Serteyn, et al. 2009. Atypical myopathy in grazing horses: a first exploratory data analysis. Vet. J. 180:77-87. doi:10.1016/j. tvjl.2008.01.016
Votion, D. M., A. Linden, C. Saegerman, P. Engels, M. Erpicum, E. Thiry, C. Delguste, S. Rouxhet, V. Demoulin, R. Navet, et al. 2007. History and clinical features of atypical myopathy in horses in Belgium (2000-2005). J. Vet. Intern. Med. 21:1380-1391. doi:10.1111/j.1939-1676.2007.tb01962.x
West, G., D. Heard, and N. Caulkett. 2014. Zoo animal and wildlife immobilization and anesthesia. 2nd ed. Wiley, New York. p. 171
Willard, M. D., and H. Tvedten. 2006. Labordiagnostik in der kleintierpraxis. [Laboratory diagnostics in small animal medicine]. 1st ed. Elsevier, München, Germany. p. 46, 296-297
Wilson, D. E., and R. A. Mittermeier. 2011. Handbook of the mammals of the world. Hoofed mammals. Vol. 2. Lynx Edicions, Barcelona, Spain. p. 425
Zuraw, A., K. Dietert, S. Kühnel, J. Sander, and R. Klopfleisch. 2016. Equine atypical myopathy caused by hypoglycin A intoxication associated with ingestion of sycamore maple tree seeds. Equine Vet. J. 48:418-421. doi:10.1111/evj.12460

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