Article (Scientific journals)
Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN).
Larocca, Alessandra; Dold, Sandra Maria; Zweegman, Sonja et al.
2018In Leukemia, 32, p. 1697-1712
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Abstract :
[en] Multiple myeloma is a disease typical of the elderly, and, because of the increase in life expectancy of the general population, its incidence is expected to grow in the future. Elderly patients represent a particular challenge due to their marked heterogeneity. Many new and highly effective drugs have been introduced in the last few years and results from clinical trials are promising. Besides the availability of novel agents, a careful evaluation of elderly patients showed to be a key factor for the success of therapy. A geriatric assessment is a valid strategy to better stratify patients. In particular, different scores are available today to appropriately assess elderly patients and define their fitness/frailty status. The choice of treatment-transplantation, triplets, doublets, or reduced-dose therapies including novel agents-should depend on the patient's fitness status (fit, intermediate-fit or frail). Second-generation novel agents have also been evaluated as salvage therapy in the elderly, and these new agents certainly represent a further step forward in the treatment armamentarium for elderly patients with multiple myeloma.
Disciplines :
Hematology
Author, co-author :
Larocca, Alessandra
Dold, Sandra Maria
Zweegman, Sonja
Terpos, Evangelos
Wasch, Ralph
D'Agostino, Mattia
Scheubeck, Sophia
Goldschmidt, Hartmut
Gay, Francesca
Cavo, Michele
Ludwig, Heinz
Straka, Christian
Bringhen, Sara
Auner, Holger W.
Caers, Jo  ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Gramatzki, Martin
Offidani, Massimo
Dimopoulos, Meletios A.
Einsele, Hermann
Boccadoro, Mario
Sonneveld, Pieter
Engelhardt, Monika
More authors (12 more) Less
Language :
English
Title :
Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN).
Publication date :
2018
Journal title :
Leukemia
ISSN :
0887-6924
eISSN :
1476-5551
Publisher :
Nature Publishing Group, United Kingdom
Volume :
32
Pages :
1697-1712
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 June 2018

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