Humans; Neoplasms/drug therapy/prevention & control; Vitamin D/therapeutic use; Vitamins/therapeutic use
Abstract :
[en] The importance of vitamin D in bone and phosphocalcic status is well recognized by the scientific and medical communities; however, recently identified properties of this cholesterol derived molecule, such as immunomodulator and anticancer activities, are yet discussed. Actually, the debate is not so much about the new vitamin D properties, but rather about the optimal concentration required to reach these properties. The difficulty in determining the norms is rendered even more complex by the existence of a vitamin D receptor gene polymorphism. The body pool of this vitamin depends essentially on its endogenous synthesis, but also on its dietary intakes. Many epidemiological studies interested in Vitamin D serum level and cancer suggest a relation between low Vitamin D level and cancer risk, especially in breast and colon adenocarcinomas. In vitro, many studies showed, in different human and animal malignant cell lines, that this molecule exerts anticancer activities: it induces apoptosis and cell differentiation as well as it inhibits proliferation and angiogenesis. This review tries to update the current knowledge on vitamin D and, more particularly, the potential interest of this molecule in cancer prevention and management.
Vuolo L, Di Somma C, Faggiano A, et al.- Vitamin D and cancer. Front Endocrinol, 2012, 3, 58.
Yin L, Grandi N, Raum E, et al.- Meta-analysis: Longitudinal studies of serum vitamin D and colorectal cancer risk. Aliment Pharmacol Ther, 2009, 30, 113-125.
Lee JE, Li H, Chan AT, et al.- Circulating levels of vitamin D and colon and rectal cancer: The Physicians' Health Study and a meta-analysis of prospective studies. Cancer Prev Res, 2011, 4, 735-743.
Ma Y, Zhang P, Wang F, et al.- Association between vitamin D and risk of colorectal cancer : A systematic review of prospective studies. J Clin Oncol, 2011, 29, 3775-3782.
Yin L, Grandi N, Raum E, et al.- Meta-analysis : serum vitamin D and breast cancer risk. Eur J Cancer, 2010, 46, 2196- 2205.
Wang D, Vélez De-La-Paz OI, Zhai JX, et al.- Serum 25-hydroxyvitamin D and breast cancer risk : A meta-analysis of prospective studies. Tumour Biol, 2013, 34, 3509-3517.
Kim Y, Je Y.- Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality : A meta-analysis. Br J Cancer, 2014, 110, 2772-2784.
Yin L, Raum E, Haug U, et al.- Meta-analysis of longitudinal studies: Serum vitamin D and prostate cancer risk. Cancer Epidemiol, 2009, 33, 435-445.
Gilbert R, Metcalfe C, Fraser WD, et al.- Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade. Int J Cancer, 2012, 131, 1187-1196.
Xu Y, Shao X, Yao Y, et al.- Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk : new findings from an updated meta-analysis. J Cancer Res Clin Oncol, 2014, 140, 1465-1477.
Reichrath J, Nürnberg B.- Cutaneous vitamin D synthesis versus skin cancer development : The Janus faces of solar UV-radiation. Dermatoendocrinol, 2009, 1, 253-261.
Tang JY, Fu T, Lau C, et al.- Vitamin D in cutaneous carcinogenesis : part II. J Am Acad Dermatol, 2012, 67, 817.
Field S, Newton-Bishop JA.- Melanoma and vitamin D. Mol Oncol, 2011, 5, 197-214.
Cheskis B, Lemon BD, Uskokovic M, et al.- Vitamin D3-retinoid X receptor dimerization, DNA binding, and transactivation are differentially affected by analogs of 1, 25-dihydroxyvitamin D3. Mol Endocrinol, 1995, 9, 1814-1824.
Naves M, Alvarez-Hernández D, Fernández-Martín JL, et al.- Effect of VDR gene polymorphisms on osteocalcin secretion in calcitriol-stimulated human osteoblasts. Kidney Int Suppl, 2003, 63, S23-S27.
Feldman D, Krishnan AV, Swami S, et al.- The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer, 2014, 14, 342-358.
Boyle BJ, Zhao XY, Cohen P, et al.- Insulin-like growth factor binding protein-3 mediates 1α, 25- dihydroxyvitamin D3 growth inhibition in the LNCaP prostate cancer cell line through p21/WAF1. J Urol, 2001, 165, 1319-1324.
Deeb KK, Trump DL, Johnson CS.- Vitamin D signalling pathways in cancer : potential for anticancer therapeutics. Nat Rev Cancer, 2007, 7, 684-700.
Krishnan AV, Feldman D.- Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol, 2011, 51, 311-336.
Mantovani A, Allavena P, Sica A, et al.- Cancer-related inflammation. Nature, 2008, 454, 436-444.
Krishnan AV, Trump DL, Johnson CS, et al.- The role of vitamin D in cancer prevention and treatment. Rheum Dis Clin North Am, 2012, 38, 161-178.
Fleet JC.- Molecular actions of vitamin D contributing to cancer prevention. Mol Aspects Med, 2008, 29, 388- 396.
Benhamou CL, Souberbielle JC, Cortet B, et al.- La vitamine D chez l'adulte : Recommandations du GRIO. Presse Med, 2011, 40, 673-682.