Reference : Study of the antioxidant action of two analgesic compounds, morphine and propofol, on...
Scientific congresses and symposiums : Poster
Physical, chemical, mathematical & earth Sciences : Physics
http://hdl.handle.net/2268/224052
Study of the antioxidant action of two analgesic compounds, morphine and propofol, on the activity of MPO and HRP
English
Nyssen, Pauline mailto [Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale >]
Mouithys-Mickalad, Ange mailto [Université de Liège - ULiège > > Centre de l'oxygène : Recherche et développement (C.O.R.D.) >]
MINGUET, Grégory mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service d'anesthésie - réanimation >]
Hoebeke, Maryse mailto [Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale >]
5-Dec-2017
No
No
National
Young Belgian Magnetic Resonance Scientist 2017
du 4 décembre au 5 décembre 2017
Blankenberge
Belgium
[en] Myeloperoxidase ; morphine ; propofol ; antioxidant activity
[en] Although acute inflammation can efficiently be treated, the treatment of chronic inflammatory pathologies is still a challenge to rise. As marker of inflammation, the enzyme Myeloperoxidase (MPO) is a choice target for the establishment of a treatment. Indeed, the uncontrolled release in the extracellular medium of MPO, marker of inflammation, along with the release of ROS, causes severe damages on biological tissues. The modulation of the enzyme activity, by an inhibitor, might constitute an approach to treat excessive inflammation. An interesting pathway is to give a second life to clinical-used molecules, presenting antioxidant and anti-inflammatory properties. According to several studies, morphine and propofol (PPF), which are already known for their analgesic and anesthetic properties, present an antioxidant activity. Therefore, these reducing molecule can potentially pretend to be MPO inhibitors.
http://hdl.handle.net/2268/224052

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