Reference : Robust and tunable bursting requires slow positive feedback
Scientific journals : Article
Engineering, computing & technology : Multidisciplinary, general & others
http://hdl.handle.net/2268/223765
Robust and tunable bursting requires slow positive feedback
English
Franci, Alessio* mailto [> >]
Drion, Guillaume* mailto [Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Sepulchre, Rodolphe* mailto [Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
* These authors have contributed equally to this work.
1-Mar-2018
Journal of Neurophysiology
American Physiological Society
119
1222-1234
Yes (verified by ORBi)
International
0022-3077
1522-1598
MD
[en] Bursting ; robustness ; modulation
[en] We highlight that the robustness and tunability of a bursting model critically rely on currents that provide slow positive feedback to the membrane potential. Such currents have the ability to make the total conductance of the circuit negative in a timescale that is termed “slow” because it is intermediate between the fast timescale of the spike upstroke and the ultraslow timescale of even slower adaptation currents. We discuss how such currents can be assessed either in voltage-clamp experiments or in computational models. We show that, while frequent in the literature, mathematical and computational models of bursting that lack the slow negative conductance are fragile and rigid. Our results suggest that modeling the slow negative con- ductance of cellular models is important when studying the neuro- modulation of rhythmic circuits at any broader scale.
http://hdl.handle.net/2268/223765
10.1152/jn.00804.2017

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