[en] We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based treatments to correct brain malformations or to prevent the progression of cell death in neurodegenerative disorders, most of these pathologies follow a fatal course. Thus, one major objective is to understand the molecular events that underlie these diseases in order to prevent their onset and/or halt their progression. Converging experimental and clinical evidences obtained by our lab and others prompt us to speculate that Elongator may be commonly targeted in different neurological disorders and as such, should represent a strong candidate for research and development efforts to design drug-based therapies.
Research Center/Unit :
GIGA Signal Transduction, GIGA-Neurosciences
Disciplines :
Neurology
Author, co-author :
Nguyen, Laurent ; Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Humbert, Sandrine
Saudou, Frédéric
Chariot, Alain ; Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Language :
English
Title :
Elongator - an emerging role in neurological disorders
Publication date :
January 2010
Journal title :
Trends in Molecular Medicine
ISSN :
1471-4914
eISSN :
1471-499X
Publisher :
Elsevier Science, Oxford, United Kingdom
Volume :
16
Pages :
1-6
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique Télévie ARC FBC
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