Paper published in a book (Scientific congresses and symposiums)
Characterization of Group B Streptococcus strains isolated from neonatal invasive diseases in Belgium, 2015.
SACHELI, Rosalie; MEEX, Cécile; DESCY, Julie et al.
2018In abstract book of 1st ISSAD 2018
Peer reviewed
 

Files


Full Text
ISSAD 2018 poster strains GBS neonatal disease.pdf
Publisher postprint (241.51 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
group B streptococcus; neonatal invasive disease; surveillance; Belgium
Abstract :
[en] Introduction Despite advances in preventive strategies, Group B Streptococcal (GBS) disease is still a leading cause of severe neonatal infections. The Belgian National Reference Centre (NRC) routinely performs surveillances of GBS invasive strains. We here provide an overview of bacteriological characteristics of GBS causing invasive diseases in infants during the year 2015. Methods All GBS strains isolated from neonatal invasive diseases sent to the NRC during the year 2015 by any laboratory located in Belgium were characterized: capsular polysaccharide (CPS)-typing by agglutination and/or with PCR, pili-typing with PCR, antimicrobial susceptibility testing, and detection of resistance genes with PCR. Results A total of 44 GBS strains isolated from neonatal invasive diseases were available: 21 from Early Onset Diseases (EOD), 23 from Late Onset Diseases (LOD). Considering the incidence of GBS infections in Belgium, this collection represents for 2015 about 40% of GBS invasive diseases. Overall, CPS-type III was predominant (54.6%) followed by Ia, Ib, II, V, IV and VI (15.9%, 11.4%, 9.1%, 4.5%, 2.3%, 2.3%). All strains were susceptible to penicillin. Resistance to macrolides and lincosamides was showed in 22.7% of the strains and mainly linked to the presence of Erm genes: ErmB gene alone was expressed in 70% of the strains (n=7), one strain harboured the combination ErmB with MefA genes and another the ErmB with LsaC genes. One resistant strain did not express any of these four genes. About pili-typing, all strains harboured one of the PI-2 variants alone or in combination: the predominant type was PI1, PI2b (36.3%) followed by PI1, PI2a (27.7%), PI2a (25%) and PI2b (11.4%). Conclusion The ratio of EOD/LOD described in Belgium in 2015 remains quite stable since a few years. CPS-type and pili-type distributions, and resistance rate to macrolides/lincosamides are quite similar to European and North American observations done during the last decade.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Laboratory medicine & medical technology
Public health, health care sciences & services
Pediatrics
Immunology & infectious disease
Author, co-author :
SACHELI, Rosalie  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
MEEX, Cécile ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
DESCY, Julie ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
HUYNEN, Pascale ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
HAYETTE, Marie-Pierre ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
MELIN, Pierrette  ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
Language :
English
Title :
Characterization of Group B Streptococcus strains isolated from neonatal invasive diseases in Belgium, 2015.
Publication date :
2018
Event name :
1st International Symposium on Streptococcus agalactiae Disease (ISSAD)
Event organizer :
Bill & Melinda Gates foundation
W.H.O.
Event place :
Cape Town, South Africa
Event date :
20th – 23rd February 2018
By request :
Yes
Audience :
International
Main work title :
abstract book of 1st ISSAD 2018
Peer reviewed :
Peer reviewed
Funders :
The national reference centre is partially supported by the Belgian Ministry of Social Affairs through a fund within the health insurance system
Available on ORBi :
since 16 May 2018

Statistics


Number of views
70 (4 by ULiège)
Number of downloads
39 (1 by ULiège)

Bibliography


Similar publications



Contact ORBi