Article (Scientific journals)
Effect of a sequential treatment combining abaloparatide and alendronate for the management of postmenopausal osteoporosis
Reginster, Jean-Yves; Al-Daghri, Nasser; Kaufman, Jean-Marc et al.
2017In Expert Opinion on Pharmacotherapy, p. 1-3
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Keywords :
Abaloparatide; osteoporosis; bisphosphonates; sequential treatment; fractures
Abstract :
[en] The recently published results of the sequential treatment of postmenopausal osteoporotic women with subcutaneous abaloparatide (80 µg/day) (ABL) for 18 months followed by 6 months of oral alendronate (70 mg/week) (ALN) support the administration of an anti-resorptive agent after completion of a treatment course with an osteoanabolic agent. The ABL/ALN sequence resulted in greater bone mineral density gains at all skeletal sites and in a reduction of vertebral, non-vertebral, major and clinical fractures compared to what is observed after 18 months of placebo followed by 6 months of ALN. Whereas questions remained unanswered about the ideal anti-resorptive agent to be used after ABL, the optimal duration of the administration of the anti-resorptive drug or the potential interest of re-initiating a course of ABL after a limited administration of ALN, these results support the use of the ABL/ALN sequence in the management of postmenopausal osteoporosis. © 2017 Informa UK Limited, trading as Taylor & Francis Group
Disciplines :
General & internal medicine
Author, co-author :
Reginster, Jean-Yves  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Al-Daghri, Nasser ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Kaufman, Jean-Marc ;  Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique
Bruyère, Olivier  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Santé publique, Epidémiologie et Economie de la santé
Language :
English
Title :
Effect of a sequential treatment combining abaloparatide and alendronate for the management of postmenopausal osteoporosis
Publication date :
2017
Journal title :
Expert Opinion on Pharmacotherapy
ISSN :
1465-6566
eISSN :
1744-7666
Publisher :
Taylor and Francis Ltd
Pages :
1-3
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 14 May 2018

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