Evidence for a long-term protection of wheel-running exercise against cocaine psychomotor sensitization in adolescent but not in adult mice

Lespine, Louis-Ferdinand; Tirelli, Ezio

doi:10.1016/j.bbr.2018.04.054

Article (Scientific journals)

Evidence for a long-term protection of wheel-running exercise against cocaine psychomotor sensitization in adolescent but not in adult mice

Lespine, Louis-Ferdinand; Tirelli, Ezio

2018 • In Behavioural Brain Research, 349, p. 63-72

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/223092

DOI
10.1016/j.bbr.2018.04.054

PubMed
29727710

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Keywords :

wheel running; long-term; cocaine sensitization; C57BL/6J; adolescence; adulthood

Abstract :

[en] Rodents housed with a running wheel can exhibit attenuated cocaine seeking and cocaine-induced psychomotor activation. However, the longevity of such a protection and the influence of the developmental stage during which exercise is displayed received little attention. Here, females and males C57BL/6J mice, aged 28 (adolescents) or 77 (adults) days were housed with (n = 56) or without (n = 28) a running wheel. After 3 weeks in these conditions, half of the exercised mice were deprived of their wheel (n = 28) whereas the other half and the sedentary mice were kept in their respective environments. After 3 additional weeks, mice were tested for initiation of psychomotor sensitization to 9 once-daily intraperitoneal injections of 8 mg/kg cocaine (following 2 drug-free sessions). The expression of sensitization was assessed on a single session 30 days after the last cocaine injection. Continuously exercised mice (wheel throughout experimentation) were less responsive to the initiation and the expression of cocaine effects, regardless of the gender and the developmental period during which exercise was introduced. A 3-week regimen of wheel-running exercise during adolescence (from 28 to 50 days of age) attenuated in later life the initiation and the expression of sensitization in females and its expression in males. In contrast, females and males previously exercised as adults (from 77 to 99 days of age) and their corresponding sedentary counterparts exhibited indiscernible levels of initiation and expression of sensitization. These results suggest that early-life period such as adolescence may be particularly sensitive to the long-term protection of exercise against cocaine vulnerability.

Disciplines :

Neurosciences & behavior

Author, co-author :

Lespine, Louis-Ferdinand ; Université de Liège - ULiège > Département de Psychologie > Neuroscience comportementale et psychopharmacologie expér.

Tirelli, Ezio ; Université de Liège - ULiège > Département de Psychologie > Neuroscience comportementale et psychopharmacologie expér.

Language :

English

Title :

Evidence for a long-term protection of wheel-running exercise against cocaine psychomotor sensitization in adolescent but not in adult mice

Publication date :

September 2018

Journal title :

Behavioural Brain Research

ISSN :

0166-4328

eISSN :

1872-7549

Publisher :

Elsevier, Netherlands

Volume :

349

Pages :

63-72

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]

Available on ORBi :

since 14 May 2018

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