Article (Scientific journals)
Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis
Gomes Da Silva, Carla; Peyre, Elise; Adhikari, M. H. et al.
2018In Cell, 172 (5), p. 1063-1067.e19
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Keywords :
MLCK
Abstract :
[en] Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers. The “stop and go” movement of individual migrating cortical interneurons is critical for ensuring a proper rate of cortical invasion for the entire population. © 2018 The Authors
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Gomes Da Silva, Carla ;  Université de Liège > GIGA - Neurosciences
Peyre, Elise ;  Université de Liège - ULiège > GIGA - Neurosciences
Adhikari, M. H.;  Center for Brain and Cognition, Department of Information and Technology, Universitat Pompeu Fabra, Calle Ramon Trias Fargas 25-27Barcelona, Spain
Tielens, Sylvia ;  Université de Liège - ULiège > Département de pharmacie > Chimie médicale
Tanco, S.;  VIB-UGent Center for Medical Biotechnologie, VIB, Ghent, Belgium, Department of Biochemistry, Ghent University, Ghent, Belgium
Van Damme, P.;  VIB-UGent Center for Medical Biotechnologie, VIB, Ghent, Belgium, Department of Biochemistry, Ghent University, Ghent, Belgium
Magno, L.;  Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London, United Kingdom
Krusy, Nathalie ;  Université de Liège - ULiège > GIGA - Neurosciences
Agirman, Gulistan ;  Université de Liège - ULiège > GIGA - Neurosciences
Magiera, M. M.;  Institut Curie, CNRS UMR3348, PSL Research University, Centre UniversitaireOrsay, France
Kessaris, N.;  Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London, United Kingdom
Malgrange, Brigitte  ;  Université de Liège - ULiège > GIGA - Neurosciences
Andrieux, A.;  Université Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Inserm, U1216Grenoble, France
Janke, C.;  Institut Curie, CNRS UMR3348, PSL Research University, Centre UniversitaireOrsay, France
Nguyen, Laurent  ;  Université de Liège - ULiège > GIGA - Neurosciences
More authors (5 more) Less
Language :
English
Title :
Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis
Publication date :
2018
Journal title :
Cell
ISSN :
0092-8674
eISSN :
1097-4172
Publisher :
Cell Press
Volume :
172
Issue :
5
Pages :
1063-1067.e19
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
108726/Z/15/Z; 2013-1-PLBIO-02-ICR-1; 2014-PLBIO-11-ICR-1; ANR-10-IDEX-0001-02 PSL; ANR-10-LBX-0038; ANR-12-BSV2-0007; ARC11/16-01,
Funders :
Wellcome Trust [GB]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
INCa - Institut National du Cancer [FR]
ANR - Agence Nationale de la Recherche [FR]
CNRS - Centre National de la Recherche Scientifique [FR]
Fonds Léon Fredericq [BE]
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