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Neuronal behaviors: A control perspective
Drion, Guillaume; O'Leary, Timothy; Dethier, Julie et al.
2015In IEEE Conference on Decision and Control, 54, p. 1923-1944
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Keywords :
Feedback; Neurophysiology; Nonlinear feedback; Physiology; Sensitivity analysis; Analytical tool; Control perspective; High-dimensional; Model principle; Model properties; Nonlinear electrical circuit; Nonlinear nature; Time-scales; Neurons
Abstract :
[en] The purpose of this tutorial is to introduce and analyze models of neurons from a control perspective and to show how recently developed analytical tools help to address important biological questions. A first objective is to review the basic modeling principles of neurophysiology in which neurons are modeled as equivalent nonlinear electrical circuits that capture their excitable properties. The specific architecture of the models is key to the tractability of their analysis: in spite of their high-dimensional and nonlinear nature, the model properties can be understood in terms of few canonical positive and negative feedback motifs localized in distinct timescales. We use this insight to shed light on a key problem in experimental neurophysiology, the challenge of understanding the sensitivity of neuronal behaviors to underlying parameters in empirically-derived models. Finally, we show how sensitivity analysis of neuronal excitability relates to robustness and regulation of neuronal behaviors. © 2015 IEEE.
Disciplines :
Engineering, computing & technology: Multidisciplinary, general & others
Author, co-author :
Drion, Guillaume ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
O'Leary, Timothy;  Brandeis University, Volen Center for Complex Systems, 415 South Street, Waltham, MA, United States
Dethier, Julie
Franci, Alessio  ;  Université de Liège - ULiège > Département d'électricité, électronique et informatique (Institut Montefiore) > Brain-Inspired Computing
Sepulchre, Rodolphe ;  Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation
Language :
English
Title :
Neuronal behaviors: A control perspective
Publication date :
2015
Event name :
54th IEEE Conference on Decision and Control, CDC 2015
Event place :
Osaka, Japan
Event date :
15 December 2015 through 18 December 2015
Audience :
International
Journal title :
IEEE Conference on Decision and Control
ISSN :
0743-1546
eISSN :
2576-2370
Publisher :
Institute of Electrical and Electronics Engineers Inc.
Special issue title :
54rd IEEE Conference on Decision and Control,CDC 2015
Volume :
54
Pages :
1923-1944
Peer reviewed :
Peer reviewed
Name of the research project :
Interuniversity Attraction Poles Programme
Funders :
BELSPO - Politique scientifique fédérale [BE]
UE - Union Européenne [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
119391 9781479978861
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