Reference : Is it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficie...
Scientific journals : Letter to the editor
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/222133
Is it possible to claim or refute sputum eosinophils ≥ 3% in asthmatics with sufficient accuracy using biomarkers?
English
Demarche, Sophie mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique et pharmacie hospitalière >]
Schleich, Florence [Université de Liège - ULiège > Département des sciences de la motricité > Département des sciences de la motricité >]
PAULUS, Virginie mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie >]
HENKET, Monique mailto [Centre Hospitalier Universitaire de Liège - CHU > > Service de pneumologie - allergologie >]
Van Hees, Thierry mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie clinique et pharmacie hospitalière >]
Louis, Renaud mailto [Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie >]
2017
Respiratory Research
BioMed Central Ltd.
18
1
133-139
Yes (verified by ORBi)
International
1465-9921
1465-993X
[en] Asthma ; Biomarkers ; Blood ; Eosinophils ; Immunoglobulin E ; Nitric oxide ; Phenotype ; Sputum ; Belgium ; Letter
[en] The concept of asthma inflammatory phenotypes has proved to be important in predicting response to inhaled corticosteroids. Induced sputum, which has been pivotal in the development of the concept of inflammatory phenotypes, is however not widely available. Several studies have proposed to use surrogate exhaled or blood biomarkers, like fractional exhaled nitric oxide (FENO), blood eosinophils and total serum immunoglobulin E (IgE). However, taken alone, each of these biomarkers has moderate accuracy to identify sputum eosinophilia. Here, we propose a new approach based on the likelihood ratio to study which thresholds of these biomarkers, taken alone or in combination, were able to rule in or rule out sputum eosinophils ≥3%. We showed in a large population of 869 asthmatics that combining FENO, blood eosinophils and total serum IgE could accurately predict sputum eosinophils ≥ or <3% in 58% of our population. © 2017 The Author(s).
http://hdl.handle.net/2268/222133
10.1186/s12931-017-0615-9

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