Reference : Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
Patent : Patent
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/221654
Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)dien-28-oyl) imidazole
English
Gribble, Gordon W. mailto [Dartmouth College > Chemistry > > >]
Sporn, Michael B. mailto [Dartmouth College > Pharmacology and Toxicology > > >]
Liby, Karen T. mailto [Dartmouth College > Pharmacology and Toxicology > > >]
Onyango, Evans O. mailto [Dartmouth College > Pharmacology and Toxicology > > >]
Cao, Martine mailto [Dartmouth College > Pharmacology and Toxicology > > >]
20-Feb-2018
2014-02-26
United States Patent and Trademark Office
US9896475B2
15/505,327 US 26-08-2015
B
Etats-Unis
TRUSTEES OF DARTMOUTH COLLEGE, HANOVER, NH, US
C07J 61/00
C07J 61/00
US
US
[en] CDDO-Im ; pyridyl analogs ; triterpenoids
[en] Pyridyl analogs of 1-(2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl) imidazole and pharmaceutical compositions containing the same are provided. The present invention is a triterpenoid compound of Formula I, or a hydrate, isomer, prodrug or pharmaceutically acceptable salt thereof: wherein one or more of R, R or R is independently a substituted or unsubstituted aryl group, heteroaryl group, cycloalkyl group or heterocyclyl group, and the remaining R groups are hydrogen. The pyridyl analogs of CD-DO-1m 1 have been developed, which are more stable in human plasma and achieve a higher concentration in target tissues such as liver, pancreas, kidney and lungs.
http://hdl.handle.net/2268/221654

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