Association between organohalogenated pollutants in cord blood and thyroid function in newborns and mothers from Belgian population

Dufour, Patrice; PIRARD, Catherine; Seghaye, Marie-Christine; Charlier, Corinne

doi:10.1016/j.envpol.2018.03.058

Article (Scientific journals)

Association between organohalogenated pollutants in cord blood and thyroid function in newborns and mothers from Belgian population

Dufour, Patrice; PIRARD, Catherine; Seghaye, Marie-Christine et al.

2018 • In Environmental Pollution, 238, p. 389-396

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/221599

DOI
10.1016/j.envpol.2018.03.058

PubMed
29579638

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Keywords :

Newborns; Perfluorinated compounds; Organochlorine pesticides; Polychlorinated biphenyls; Thyroid

Abstract :

[en] The last decades have seen the increasing prevalence of thyroid disorders. These augmentations could be the consequence of the increasing contamination of the environment by chemicals that may disrupt the thyroid function. Indeed, in vitro studies have shown that many chemicals contaminating our environment and highlighted in human serum, are able to interfere with the thyroid function. Given the crucial importance of thyroid hormones on neurodevelopment in fetus and newborns, the influence of these pollutants on newborn thyroid homeostasis is a major health concern. Unfortunately, the overall evidence for a deleterious influence of environmental pollutants on thyroid remains poorly studied. Therefore, we assessed the contamination by polychlorinated biphenyls (PCBs), organochlorine pesticides and perfluorinated compounds (PFC) in 221 cord blood samples collected in Belgium between 2013 and 2016. Our results showed that compared to previous studies performed on newborns recruited in Belgium during the two last decades, the present pollutant contamination is declining. Multivariate statistical analyses pointed out a decrease of thyroid stimulating hormone (TSH) level in male newborns with detectable level of 4,40- dichlorodiphenyldichloroethylene (4,40-DDE) in comparison with those with no detectable level (p ¼ 0.025). We also highlighted a negative association between perfluorononanoic acid (PFNA) concentration and TSH in male newborns (p ¼ 0.018). Logistic regression showed increased odds ratio for presentation of hypothyroid in mother for each one unit augmentation of log natural concentration of PFOA (OR ¼ 2.30, [1.18e4.5]) and PFOS (OR ¼ 2.03 [1.08e3.83]). Our findings showed that the residual contamination by PFCs and organochlorine pollutants in cord blood are correlated with thyroid hormone in the newborns and the risk of hypothyroid in mothers.

Disciplines :

Pharmacy, pharmacology & toxicology

Author, co-author :

Dufour, Patrice ; Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique

PIRARD, Catherine ; Centre Hospitalier Universitaire de Liège - CHU > Service de toxicologie

Seghaye, Marie-Christine ; Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie cardiologique et pneumologique

Charlier, Corinne ; Université de Liège - ULiège > Département de pharmacie > Chimie toxicologique

Language :

English

Title :

Association between organohalogenated pollutants in cord blood and thyroid function in newborns and mothers from Belgian population

Publication date :

2018

Journal title :

Environmental Pollution

ISSN :

0013-9327

Publisher :

Applied Science Publishers, United Kingdom

Volume :

238

Pages :

389-396

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 27 March 2018

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