Continuous Flow Organic Chemistry: Successes and Pitfalls at the Interface with Current Societal Challenges

Gerardy, Romaric; Emmanuel, Noémie; Toupy, Thomas; Kassin, Victor-Emmanuel; Tshibalonza Ntumba, Nelly; Schmitz, Michaël; Monbaliu, Jean-Christophe

doi:10.1002/ejoc.201800149

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Continuous Flow Organic Chemistry: Successes and Pitfalls at the Interface with Current Societal Challenges

Gerardy, Romaric; Emmanuel, Noémie; Toupy, Thomas et al.

2018 • In European Journal of Organic Chemistry

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https://hdl.handle.net/2268/221316

DOI
10.1002/ejoc.201800149

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Keywords :

Flow chemistry; Orphan drugs; Essential drugs; Drug shortages; Perspectives; Platform molecules

Abstract :

[en] This review intends to provide the reader with a clear and concise overview of how preparative continuous flow organic chemistry could potentially impact on current important societal challenges. These societal challenges include health/well-being and sustainable development. Continuous flow chemistry has enabled significant advances for the manufacturing of pharmaceuticals, as well as for biomass valorization toward a biosourced chemical industry. Examples related to pharmaceutical production are herein focused on (a) the implementation of flow chemistry to reduce the occurrence of drug shortages, (b) continuous flow manufacturing of orphan drugs, (c) continuous flow preparation of active pharmaceuticals listed on the WHO list of essential medicines and (d) perspectives for the manufacturing of peptide-based pharmaceuticals. Examples related to sustainable development are focused on the valorization of biosourced platform molecules. Besides positive impacts on societal challenges, this review also illustrates some of the potentially most threatening perspectives of continuous flow technology within the actual context of terrorism and drug abuse.

Disciplines :

Chemistry

Author, co-author :

Gerardy, Romaric ; Université de Liège - ULiège > Département de chimie (sciences) > CITOS

Emmanuel, Noémie ; Université de Liège - ULiège > Département de chimie (sciences) > CITOS

Toupy, Thomas ; Université de Liège - ULiège > Département de chimie (sciences) > CITOS

Kassin, Victor-Emmanuel ; Université de Liège - ULiège > Département de chimie (sciences) > CITOS

Tshibalonza Ntumba, Nelly

Schmitz, Michaël ; Université de Liège - ULiège > Département de chimie (sciences) > Département de chimie (sciences)

Monbaliu, Jean-Christophe ; Université de Liège - ULiège > Département de chimie (sciences) > CITOS

Language :

English

Title :

Continuous Flow Organic Chemistry: Successes and Pitfalls at the Interface with Current Societal Challenges

Publication date :

2018

Journal title :

European Journal of Organic Chemistry

ISSN :

1434-193X

eISSN :

1099-0690

Publisher :

John Wiley & Sons, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://onlinelibrary.wiley.com/doi/10.1002/ejoc.201800149/full

Available on ORBi :

since 15 March 2018

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166

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155

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Calculations were performed using the computing resources of the computing center of RWTH Aachen.
Calculations were performed with the SPINOL-derived N-triflyl phosphoramide catalyst 5 a and aza-o-QM derived from (2-methylaminophenyl)(phenyl)methanol. For further theoretical studies involving N-triflyl phosphoramide catalysts, see:
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