[en] Radiotherapy is known for its action on local tumoral control. However, it is also able to induce immunomodulatory effects at a systemic level. The abscopal effect (from latin ab scopus which means <<away from the target>>) is an illustration of this phenomenon. It is defined as a tumor regression observed outside and at a distance of the irradiation fields. The potential application of this effect of treatment in disseminated cancers is a fast-growing field of research. The optimal therapeutic strategy to achieve this effect remains unknown.
Disciplines :
Oncology
Author, co-author :
PLEYERS, Clémence ; Centre Hospitalier Universitaire de Liège - CHU > > Service médical de radiothérapie
PIRET, Pascal ; Centre Hospitalier Universitaire de Liège - CHU > Département de Physique Médicale > Service médical de radiothérapie
RORIVE, Andrée ; Centre Hospitalier Universitaire de Liège - CHU > Service d'oncologie médicale
Coucke, Philippe ; Université de Liège - ULiège > Département des sciences cliniques > Radiothérapie
Language :
French
Title :
Peut-on considérer que la radiothérapie agit en dehors du site irradié ? L'effet abscopal.
Alternative titles :
[en] Could we consider that radiotherapy is effective outside the irradiation area ? The abscopal effect
Publication date :
2018
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Levy A, Chargari C, Marabelle A, et al.- Can immunostimulatory agents enhance the abscopal effect of radiotherapy? Eur J Cancer, 2016, 62, 36-45.
Mole RH.- Whole body irradiation; radiobiology or medicine? Br J Radiol, 1953, 26, 234-241.
Formenti SC, Demaria S.- Systemic effects of local radiotherapy. Lancet Oncol, 2009, 10, 718-726
Ryungsa K, Manabu E, Kazuaki T.- Cancer immunoediting from immune surveillance to immune escape. Immunology, 2007, 121, 1-14.
Deutsch E, Lévy A, Chargari C.- Radiothérapie et immunomodulation : mise au point sur les données expérimentales. Cancer/Radiothérapie, 2015, 19, 515-518.
Vatner RE, Cooper BT, Vanpouille-Box C, et al.- Combinations of immunotherapy and radiation in cancer therapy. Front Oncol, 2014, 4, 1-15.
Deloch L, Derer A, Hartmann J, et al.- Modern radiotherapy concepts and the impact of radiation on immune activation. Front Oncol, 2016, 6, 1-7.
Lumniczky K, Sáfrány G.- The impact of radiation therapy on the antitumor immunity: Local effects and systemic consequences. Cancer Letters, 2015, 356, 114-125.
Demaria S, Golden EB, Formenti SC.- Role of local radiation therapy in cancer immunotherapy. JAMA Oncol, 2015, 1, 1325-1332.
Demaria S., Bhardwaj N., Mc Bride W.H, et al.- Combining radiotherapy and immunotherapy : a revived partnership. Int J Radiation Oncology Biol Phys, 2005, 63, 655-666.
Wrzesinski SH, Wan YY, Flavell RA.- Transforming growth factor-beta and the immune response: implications for anticancer therapy. Clin Cancer Res, 2007, 13, 5262-5270.
Formenti SC, Demaria S.- Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst, 2013, 105, 256-265.
Suna R, Sbaib A, Ganemc G, et al.- Effets non ciblés (bystander, abscopal) de la radiothérapie externe : potentielles implications pour le clinicien ? Cancer/Radiothérapie, 2014, 18, 770-778.
Grass GD, Niveditha K, Sungjune K.- The immune mechanisms of abscopal effect in radiation therapy. Curr Probl Cancer, 2016, 40, 10-24.
Reynders K, Illidge T, Siva S, et al.- The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev, 2015, 41, 503-510.
Demaria S, Ng B, Devitt ML, et al.- Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys, 2004, 58, 862-870.
Demaria S, Kawashima N, Yang AM, et al.- Immune-mediated inhibition of metastases after treatment with local radiation and CTLA-4 blockade in a mouse model of breast cancer. Clin Cancer Res, 2005, 11, 728-734.
Dewan MZ, Galloway AE, Kawashima N, et al.- Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibody. Clin Cancer Res, 2009, 15, 5379-5388.
