Hybrid plasmonic multichannel spectroscopic sensor platform

we present a hybrid plasmonic sensor concept, as well as the first proof-of-concept experimental investigations, demonstrating its practical feasibility. The proposed approach gives access to two detection formats on the same lab-on-chip device: surface plasmon resonance (SPR) and localized surface plasmon resonance (LSPR) biosensing . The developed instrumental platform is dedicated to multichannel biosensing. In order to implement the proposed sensing approach, we developed a specific microfabrication technique involving gold nanoparticles (Au_NPs) synthesis by pulsed laser writing followed by annealing. This technology provides powerful tools for flexible patterning of the microfluidic sensor chips with array of different SPR and LSPR probes.
The optical properties of synthesized NPs have been investigated using specially developed equipment involving total internal reflectance ellipsometric spectroscopy (TIR_ES). We experimentally demonstrate that the use of the TIR-based optical readout can significantly enhance the LSPR sensor sensibility to refraction index variations of the liquid sample.