Reference : Study of the role of the complex formed by the Varicella Zoster virus ORF9p and the c...
Scientific congresses and symposiums : Poster
Life sciences : Microbiology
http://hdl.handle.net/2268/220414
Study of the role of the complex formed by the Varicella Zoster virus ORF9p and the cellular Adaptin Protein-1 in the secondary egress
English
Lambert, Julien mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie >]
Lebrun, Marielle mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie >]
Riva, Laura [> >]
Sanchez Gil, Judith mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie >]
Sadzot-Delvaux, Catherine mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie >]
Andrei, Graciela [> >]
Snoeck, Robert [> >]
29-Jul-2017
A0
No
No
International
IHW 2017
du 29 juillet 2017 au 02 août 2017
Ghent
Belgique
[en] VZV egress ; ORF9p ; Adaptor protein complex 1
[en] ORF9p (homologous to HSV-1 VP22) is a VZV tegument protein essential for the viral replication. We have shown that ORF9p co-immunoprecipitates with the cellular clathrine Adaptor Protein-1 (AP-1) complex and have identified the leucine 231 as important for this interaction. The mutation of this residue strongly impairs the virus replication in MRC-5 cells and in a 3D-skin model. These observations suggest that the interaction between ORF9p and AP-1 is important for VZV replication and envelopment. In this context, the role of the ORF9p/AP-1 complex in the secondary envelopment has been further investigated.
Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (Communauté française de Belgique) - FRIA ; ULiège
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/220414

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