[en] ORF9p (homologous to HSV-1 VP22) is a VZV tegument protein essential for the viral replication. We have shown that ORF9p co-immunoprecipitates with the cellular clathrine Adaptor Protein-1 (AP-1) complex and have identified the leucine 231 as important for this interaction. The mutation of this residue strongly impairs the virus replication in MRC-5 cells and in a 3D-skin model. These observations suggest that the interaction between ORF9p and AP-1 is important for VZV replication and envelopment. In this context, the role of the ORF9p/AP-1 complex in the secondary envelopment has been further investigated.
Disciplines :
Microbiology
Author, co-author :
Lambert, Julien ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie
Lebrun, Marielle ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie
Riva, Laura
Sanchez Gil, Judith ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie
Sadzot-Delvaux, Catherine ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Virologie et immunologie
Other collaborator :
Andrei, Graciela
Snoeck, Robert
Language :
English
Title :
Study of the role of the complex formed by the Varicella Zoster virus ORF9p and the cellular Adaptin Protein-1 in the secondary egress
Publication date :
29 July 2017
Number of pages :
A0
Event name :
IHW 2017
Event place :
Ghent, Belgium
Event date :
du 29 juillet 2017 au 02 août 2017
Audience :
International
Funders :
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture ULiège - Université de Liège
