Reference : Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
http://hdl.handle.net/2268/220169
Inflammation-Generated Extracellular Matrix Fragments Drive Lung Metastasis
English
BEKAERT, Sandrine []
Fillet, Marianne mailto [Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments >]
Detry, Benoit []
Pichavant, Muriel []
Marée, Raphaël mailto [Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Systèmes et modélisation >]
Noël, Agnès mailto [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
Rocks, Natacha mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacie galénique >]
Cataldo, Didier mailto [Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement >]
21-Dec-2017
Cancer Growth and Metastasis
Sage Journals
10
1-11
Yes
International
1179-0644
[en] lung metastasis ; microenvironment ; neutrophilic inflammation ; MMP-9 ; ac-PGP ; matrikine ; CXCR2
[en] Mechanisms explaining the propensity of a primary tumor to metastasize to a specific site still need to be unveiled, and clinical studies support a link between chronic inflammation and cancer dissemination to specific tissues. Using different mouse models, we demonstrate the role of inflammation-generated extracellular matrix fragments ac-PGP (N-acetyl-proline-glycine-proline) on tumor cells dissemination to lung parenchyma. In mice exposed to cigarette smoke or lipopolysaccharide, lung neutrophilic inflammation produces increased levels of MMP-9 (matrix metalloproteinase 9) that contributes to collagen breakdown and allows the release of ac-PGP tripeptides. By silencing CXCR2 gene expression in tumor cells, we show that these generated ac-PGP tripeptides exert a chemotactic activity on tumor cells in vivo by binding CXCR2.
http://hdl.handle.net/2268/220169
10.1177/1179064417745539

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