Article (Scientific journals)
Polyamines in gut inflammation and allergy
Peulen, Olivier; Deloyer, Patricia; Deville, Christelle et al.
2004In Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents, 3, p. 1-8
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Keywords :
polyamines; GI Tract; inflammation; allergy; probiotic
Abstract :
[en] The natural polyamines, named 1,4-diaminobutane, N-aminopropyl-1,4-diaminobutane and N,N'-bisaminopropyl- 1,4-diaminobutane, are also designated respectively as putrescine, spermidine and spermine. They are polycationic compounds found in all eukaryotic cells. As they are deeply involved in cell functions, e.g. cellular growth, their concentration and their equilibrium in the intracellular pool are maintained in very narrow limits by regulatory mechanisms acting in a very fast, sensitive and precise way. These compounds are involved in gut inflammatory processes and in allergy. Indeed, they control the production of inflammatory mediators in several cell lines or tissues. Polyamine metabolism could be considered as a putative target for inflammation, allergy prevention or therapy.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Peulen, Olivier  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Deloyer, Patricia
Deville, Christelle ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Dandrifosse, Guy ;  Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine)
Language :
English
Title :
Polyamines in gut inflammation and allergy
Publication date :
2004
Journal title :
Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents
ISSN :
1568-0142
Publisher :
Bentham Science Publishers Ltd.
Volume :
3
Pages :
1-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 September 2009

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