Article (Scientific journals)
How Does HTLV-1 Undergo Oncogene-Dependent Replication Despite a Strong Immune Response?
Gazon, Hélène; Chauhan, Pradeep Singh; Hamaïdia, Malik et al.
2018In Frontiers in Microbiology, 8, p. 2684
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Keywords :
BLV; HTLV; microRNA; cytotoxic T cells; long non-coding RNA; Leukemia
Abstract :
[en] In 1987, Mitsuaki Yoshida proposed the following model (Yoshida and Seiki, 1987): “... T-cells activated through the endogenous p40x would express viral antigens including the envelope glycoproteins which are exposed on the cell surface. These glycoproteins are targets of host immune surveillance, as is evidenced by the cytotoxic effects of antienvelope antibodies or patient sera. Eventually all cells expressing the viral antigens, that is, all cells driven by the p40x would be rejected by the host. Only those cells that did not express the viral antigens would survive. Later, these antigen-negative infected cells would begin again to express viral antigens, including p40x, thus entering into the second cycle of cell propagation. These cycles would be repeated in so-called healthy virus carriers for 20 or 30 years or longer....” Three decades later, accumulated experimental facts particularly on intermittent viral transcription and regulation by the host immune response appear to prove that Yoshida was right. This Hypothesis and Theory summarizes the evidences that support this paradigm.
Research center :
Gembloux Agro-Bio Tech - University of Liège
Disciplines :
Oncology
Biochemistry, biophysics & molecular biology
Author, co-author :
Gazon, Hélène ;  Université de Liège - ULiège > GIGA-R : Epigénétique Cellulaire et Moléculaire
Chauhan, Pradeep Singh ;  Université de Liège - ULiège > GIGA-R : Epigénétique Cellulaire et Moléculaire
Hamaïdia, Malik  ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
Hoyos, Clotilde ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
Li, Lin ;  Université de Liège - ULiège > Doct. sc. agro. & ingé. biol. (Paysage)
Safari, Roghaiyeh
Willems, Luc  ;  Université de Liège - ULiège > GIGA Cancer - Cellular and Molecular Epigenetics
Language :
English
Title :
How Does HTLV-1 Undergo Oncogene-Dependent Replication Despite a Strong Immune Response?
Publication date :
2018
Journal title :
Frontiers in Microbiology
eISSN :
1664-302X
Publisher :
Frontiers Media S.A., Switzerland
Special issue title :
HYPOTHESIS AND THEORY
Volume :
8
Pages :
Article 2684
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
Virus-host interplay at the early phases of infection
The Interuniversity Attraction Poles (IAP)
Program “Virus-host interplay at the early phases of infection” BELVIR initiated by the Belgian Science Policy Office
AgricultureIsLife
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
BELSPO - Politique scientifique fédérale [BE]
Belgian Foundation Against Cancer [BE]
CAC - Centre anticancéreux près l'Université de Liège asbl [BE]
ULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech [BE]
ULg FSR - Université de Liège. Fonds spéciaux pour la recherche [BE]
Funding text :
The “Plan Cancer” of the Service Public Fédéral
Available on ORBi :
since 31 January 2018

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